Considering clonal hematopoiesis of indeterminate potential in space radiation risk analysis for hematologic cancers and cardiovascular disease.

Autor: Werneth CM; NASA Langley Research Center, Hampton, VA, USA. charles.m.werneth@nasa.gov., Patel ZS; Center for Scientific Review, National Institutes of Health, Bethesda, MD, USA., Thompson MS; NASA Lyndon B. Johnson Space Center, Houston, TX, USA., Blattnig SR; NASA Langley Research Center, Hampton, VA, USA., Huff JL; NASA Langley Research Center, Hampton, VA, USA.
Jazyk: angličtina
Zdroj: Communications medicine [Commun Med (Lond)] 2024 Jun 11; Vol. 4 (1), pp. 105. Date of Electronic Publication: 2024 Jun 11.
DOI: 10.1038/s43856-023-00408-4
Abstrakt: Background: Expanding human presence in space through long-duration exploration missions and commercial space operations warrants improvements in approaches for quantifying crew space radiation health risks. Currently, risk assessment models for radiogenic cancer and cardiovascular disease consider age, sex, and tobacco use, but do not incorporate other modifiable (e.g., body weight, physical activity, diet, environment) and non-modifiable individual risk factors (e.g., genetics, medical history, race/ethnicity, family history) that may greatly influence crew health both in-mission and long-term. For example, clonal hematopoiesis of indeterminate potential (CHIP) is a relatively common age-related condition that is an emerging risk factor for a variety of diseases including cardiovascular disease and cancer. CHIP carrier status may therefore exacerbate health risks associated with space radiation exposure.
Methods: In the present study, published CHIP hazard ratios were used to modify background hazard rates for coronary heart disease, stroke, and hematologic cancers in the National Aeronautics and Space Administration space radiation risk assessment model. The risk of radiation exposure-induced death for these endpoints was projected for a future Mars exploration mission scenario.
Results: Here we show appreciable increases in the lifetime risk of exposure-induced death for hematologic malignancies, coronary heart disease, and stroke, which are observed as a function of age after radiation exposure for male and female crew members that are directly attributable to the elevated health risks for CHIP carriers.
Conclusions: We discuss the importance of evaluating individual risk factors such as CHIP as part of a comprehensive space radiation risk assessment strategy aimed at effective risk communication and disease surveillance for astronauts embarking on future exploration missions.
(© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze: MEDLINE
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