Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction.

Autor:	Siew K; London Tubular Centre, Department of Renal Medicine, University College London, London, UK. k.siew@ucl.ac.uk., Nestler KA; The Institute for Biomedical Sciences (IBS), The George Washington University, Washington, DC, USA., Nelson C; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., D'Ambrosio V; London Tubular Centre, Department of Renal Medicine, University College London, London, UK.; Department of Experimental and Translational Medicine, Università Cattolica del Sacro Cuore di Roma, Rome, Italy., Zhong C; London Tubular Centre, Department of Renal Medicine, University College London, London, UK., Li Z; London Tubular Centre, Department of Renal Medicine, University College London, London, UK.; Centre for Advanced Biomedical Imaging, University College London, London, UK.; Centre for Computational Medicine, University College London, London, UK., Grillo A; London Tubular Centre, Department of Renal Medicine, University College London, London, UK., Wan ER; London Tubular Centre, Department of Renal Medicine, University College London, London, UK., Patel V; Department of Renal Medicine, University College London, London, UK., Overbey E; Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA., Kim J; Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA., Yun S; University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Vaughan MB; School of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland.; Tissue Engineering and Biomaterials Group, Ghent University, Ghent, Belgium.; Center for Medical Genetics, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium., Cheshire C; Bioinformatics and Computational Biology Laboratory, The Francis Crick Institute, London, UK., Cubitt L; Applied Biotechnology Laboratory, The Francis Crick Institute, London, UK., Broni-Tabi J; Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK., Al-Jaber MY; Anti-Doping Laboratory Qatar, Doha, Qatar., Boyko V; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA., Meydan C; Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA., Barker P; MRC MDU Mouse Biochemistry Laboratory, University of Cambridge, Cambridge, UK., Arif S; Center for Data Driven Discovery in Biomedicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Neurosurgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Afsari F; Department of Medicine-Nephrology & Intelligent Critical Care Center, University of Florida, Gainesville, FL, USA., Allen N; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA., Al-Maadheed M; Anti-Doping Laboratory Qatar, Doha, Qatar.; Centre of Metabolism and Inflammation, University College London, London, UK., Altinok S; School of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Bah N; Applied Biotechnology Laboratory, The Francis Crick Institute, London, UK., Border S; Department of Medicine-Nephrology & Intelligent Critical Care Center, University of Florida, Gainesville, FL, USA., Brown AL; Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Burling K; MRC MDU Mouse Biochemistry Laboratory, University of Cambridge, Cambridge, UK., Cheng-Campbell M; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.; Blue Marble Space Institute of Science, Seattle, WA, USA., Colón LM; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA., Degoricija L; KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA., Figg N; Department of Medicine, University of Cambridge, Cambridge, UK., Finch R; School of Health, Science and Wellbeing, Staffordshire University, Stoke-on-Trent, UK., Foox J; Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA., Faridi P; Monash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., French A; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA., Gebre S; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA., Gordon P; Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK., Houerbi N; Physiology, Biophysics & Systems Biology, Weill Cornell Medical College, New York, NY, USA., Valipour Kahrood H; Monash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.; Monash Bioinformatics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Kiffer FC; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Klosinska AS; Division of Experimental Medicine & Immunotherapeutics (EMIT), Department of Medicine, University of Cambridge, Cambridge, UK., Kubik A; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA., Lee HC; Monash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Li Y; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China., Lucarelli N; Department of Medicine-Nephrology & Intelligent Critical Care Center, University of Florida, Gainesville, FL, USA., Marullo AL; School of Medicine, College of Medicine and Health, University College Cork, Cork, Ireland., Matei I; Cornell Center for Immunology, Cornell University, Ithaca, NY, USA.; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medical College, New York, NY, USA., McCann CM; Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Mimar S; Department of Medicine-Nephrology & Intelligent Critical Care Center, University of Florida, Gainesville, FL, USA., Naglah A; Department of Medicine-Nephrology & Intelligent Critical Care Center, University of Florida, Gainesville, FL, USA., Nicod J; Advanced Sequencing Facility, The Francis Crick Institute, London, UK., O'Shaughnessy KM; Division of Experimental Medicine & Immunotherapeutics (EMIT), Department of Medicine, University of Cambridge, Cambridge, UK., Oliveira LC; Blue Marble Space Institute of Science, Seattle, WA, USA.; Federal University of São Paulo (UNIFESP), São Paulo, Brazil., Oswalt L; Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Patras LI; Pediatrics, Weill Cornell Medical College, New York, NY, USA., Lai Polo SH; KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA., Rodríguez-Lopez M; Advanced Sequencing Facility, The Francis Crick Institute, London, UK., Roufosse C; Department of Immunology and Inflammation, Imperial College London, London, UK., Sadeghi-Alavijeh O; Department of Renal Medicine, University College London, London, UK., Sanchez-Hodge R; Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Paul AS; Department of Medicine-Nephrology & Intelligent Critical Care Center, University of Florida, Gainesville, FL, USA., Schittenhelm RB; Monash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Schweickart A; Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA.; Englander Institute for Precision Medicine, Weill Cornell Medical College, New York, NY, USA., Scott RT; KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA., Choy Lim Kam Sian TC; Monash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., da Silveira WA; School of Health, Science and Wellbeing, Staffordshire University, Stoke-on-Trent, UK.; International Space University, 67400, Illkirch-Graffenstaden, France., Slawinski H; Advanced Sequencing Facility, The Francis Crick Institute, London, UK., Snell D; Advanced Sequencing Facility, The Francis Crick Institute, London, UK., Sosa J; University Health Network, Toronto, ON, Canada., Saravia-Butler AM; KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA., Tabetah M; Department of Agricultural and Biological Engineering, Purdue University, West Lafayette, IN, USA., Tanuwidjaya E; Monash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Walker-Samuel S; Centre for Advanced Biomedical Imaging, University College London, London, UK.; Centre for Computational Medicine, University College London, London, UK., Yang X; Proteomics, King's College London, London, UK., Yasmin; Division of Experimental Medicine & Immunotherapeutics (EMIT), Department of Medicine, University of Cambridge, Cambridge, UK., Zhang H; Monash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Godovac-Zimmermann J; Department of Renal Medicine, University College London, London, UK., Sarder P; Department of Medicine-Quantitative Health Section, University of Florida, Gainesville, FL, USA.; Departments of Biomedical Engineering and Electrical and Computer Engineering, University of Florida, Gainesville, FL, USA., Sanders LM; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.; Blue Marble Space Institute of Science, Seattle, WA, USA., Costes SV; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA., Campbell RAA; Sainsbury Wellcome Centre for Neural Circuits and Behaviour, University College London, London, UK., Karouia F; Blue Marble Space Institute of Science, Seattle, WA, USA.; Space Research Within Reach, San Francisco, CA, USA.; Center for Space Medicine, Baylor College of Medicine, Houston, TX, USA., Mohamed-Alis V; Anti-Doping Laboratory Qatar, Doha, Qatar.; Centre of Metabolism and Inflammation, University College London, London, UK., Rodriques S; Applied Biotechnology Laboratory, The Francis Crick Institute, London, UK., Lynham S; Proteomics, King's College London, London, UK., Steele JR; Monash Proteomics and Metabolomics Platform, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia., Baranzini S; Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA., Fazelinia H; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia Research Institute, Philadelphia, PA, USA., Dai Z; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China., Uruno A; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan., Shiba D; Mouse Epigenetics Project, ISS/Kibo experiment, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Ibaraki, Japan.; JEM Utilization Center, Human Spaceflight Technology Directorate, Japan Aerospace Exploration Agency (JAXA), Tsukuba, Ibaraki, Japan., Yamamoto M; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.; Department of Medical Biochemistry, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan., A C Almeida E; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA., Blaber E; Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA.; Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA.; Stanley Center for Psychiatric Research, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA., Schisler JC; Pharmacology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Eisch AJ; Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Muratani M; Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan., Zwart SR; Department of Preventative Medicine and Community Health, University of Texas Medical Branch, Galveston, TX, USA., Smith SM; NASA Johnson Space Center, Houston, TX, USA., Galazka JM; Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA., Mason CE; Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY, USA.; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medical College, New York, NY, USA.; The Feil Family Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY, USA., Beheshti A; KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA, USA.; Broad Institute, Cambridge, MA, USA.; Space Biosciences Division, Universities Space Research Association (USRA), Washington, DC, USA., Walsh SB; London Tubular Centre, Department of Renal Medicine, University College London, London, UK. stephen.walsh@ucl.ac.uk.
Jazyk:	angličtina
Zdroj:	Nature communications [Nat Commun] 2024 Jun 11; Vol. 15 (1), pp. 4923. Date of Electronic Publication: 2024 Jun 11.
DOI:	10.1038/s41467-024-49212-1
Abstrakt:	Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored. We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) and morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using samples and datasets available from 11 spaceflight-exposed mouse and 5 human, 1 simulated microgravity rat and 4 simulated GCR-exposed mouse missions. We found that spaceflight induces: 1) renal transporter dephosphorylation which may indicate astronauts' increased risk of nephrolithiasis is in part a primary renal phenomenon rather than solely a secondary consequence of bone loss; 2) remodelling of the nephron that results in expansion of distal convoluted tubule size but loss of overall tubule density; 3) renal damage and dysfunction when exposed to a Mars roundtrip dose-equivalent of simulated GCR. (© 2024. The Author(s).)
Databáze:	MEDLINE
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