Roles of feedback and feed-forward networks of dopamine subsystems: insights from Drosophila studies.

Autor:	Davidson AM; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.; Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Hige T; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA hige@email.unc.edu.; Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.; Integrative Program for Biological and Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Jazyk:	angličtina
Zdroj:	Learning & memory (Cold Spring Harbor, N.Y.) [Learn Mem] 2024 Jun 11; Vol. 31 (5). Date of Electronic Publication: 2024 Jun 11 (Print Publication: 2024).
DOI:	10.1101/lm.053807.123
Abstrakt:	Across animal species, dopamine-operated memory systems comprise anatomically segregated, functionally diverse subsystems. Although individual subsystems could operate independently to support distinct types of memory, the logical interplay between subsystems is expected to enable more complex memory processing by allowing existing memory to influence future learning. Recent comprehensive ultrastructural analysis of the Drosophila mushroom body revealed intricate networks interconnecting the dopamine subsystems-the mushroom body compartments. Here, we review the functions of some of these connections that are beginning to be understood. Memory consolidation is mediated by two different forms of network: A recurrent feedback loop within a compartment maintains sustained dopamine activity required for consolidation, whereas feed-forward connections across compartments allow short-term memory formation in one compartment to open the gate for long-term memory formation in another compartment. Extinction and reversal of aversive memory rely on a similar feed-forward circuit motif that signals omission of punishment as a reward, which triggers plasticity that counteracts the original aversive memory trace. Finally, indirect feed-forward connections from a long-term memory compartment to short-term memory compartments mediate higher-order conditioning. Collectively, these emerging studies indicate that feedback control and hierarchical connectivity allow the dopamine subsystems to work cooperatively to support diverse and complex forms of learning. (© 2024 Davidson and Hige; Published by Cold Spring Harbor Laboratory Press.)
Databáze:	MEDLINE
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