Drosophila learning and memory centers and the actions of drugs of abuse.

Autor:	Larnerd C; Quantitative and Systems Biology Graduate Group, University of California, Merced, California 95343, USA., Kachewar N; Department of Molecular and Cell Biology, University of California, Merced, California 95343, USA.; Health Sciences Research Institute, University of California, Merced, California 95343, USA., Wolf FW; Quantitative and Systems Biology Graduate Group, University of California, Merced, California 95343, USA fwolf@ucmerced.edu.; Department of Molecular and Cell Biology, University of California, Merced, California 95343, USA.
Jazyk:	angličtina
Zdroj:	Learning & memory (Cold Spring Harbor, N.Y.) [Learn Mem] 2024 Jun 11; Vol. 31 (5). Date of Electronic Publication: 2024 Jun 11 (Print Publication: 2024).
DOI:	10.1101/lm.053815.123
Abstrakt:	Drug addiction and the circuitry for learning and memory are intimately intertwined. Drugs of abuse create strong, inappropriate, and lasting memories that contribute to many of their destructive properties, such as continued use despite negative consequences and exceptionally high rates of relapse. Studies in Drosophila melanogaster are helping us understand how drugs of abuse, especially alcohol, create memories at the level of individual neurons and in the circuits where they function. Drosophila is a premier organism for identifying the mechanisms of learning and memory. Drosophila also respond to drugs of abuse in ways that remarkably parallel humans and rodent models. An emerging consensus is that, for alcohol, the mushroom bodies participate in the circuits that control acute drug sensitivity, not explicitly associative forms of plasticity such as tolerance, and classical associative memories of their rewarding and aversive properties. Moreover, it is becoming clear that drugs of abuse use the mushroom body circuitry differently from other behaviors, potentially providing a basis for their addictive properties. (© 2024 Larnerd et al.; Published by Cold Spring Harbor Laboratory Press.)
Databáze:	MEDLINE
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