[Delayed diagnosis of osteosarcoma in adults: a prognostic factor to be considered].

Autor: Clara-Altamirano MA; Departamento De Piel y Partes Blandas, Instituto Nacional de Cancerología (INCan). Ciudad de México. México., García-Ortega DY; Departamento De Piel y Partes Blandas, Instituto Nacional de Cancerología (INCan). Ciudad de México. México., Álvarez-Cano A; Hospital Christus Muguerza Alta Especialidad. Monterrey, Nuevo León, México., Velázquez-Rodríguez S; Instituto Nacional de Cancerología (INCan). Ciudad de México. México., Lizcano-Suárez AR; Instituto del Cáncer del Hospital Internacional de Colombia., Rosas LC; Instituto Nacional de Cancerología (INCan). Ciudad de México. México., Uribe-Saloma CE; Hospital Pediátrico de San Juan de Aragón. Ciudad de México. México., Martínez-Said H; Instituto Nacional de Cancerología (INCan). Ciudad de México. México., Villavicencio-Valencia V; Departamento De Piel y Partes Blandas, Instituto Nacional de Cancerología (INCan). Ciudad de México. México., Cuellar-Hubbe M; Departamento De Piel y Partes Blandas, Instituto Nacional de Cancerología (INCan). Ciudad de México. México.
Jazyk: Spanish; Castilian
Zdroj: Acta ortopedica mexicana [Acta Ortop Mex] 2024 May-Jun; Vol. 38 (3), pp. 164-171.
DOI: 10.35366/115811
Abstrakt: Introduction: different variables have been associated with a worse prognosis of patients with osteosarcoma (OS), highlighting tumor size, location in the axial skeleton and the presence of metastases. The objective of this study is to analyze the prognostic impact of diagnostic delay in osteosarcoma in adults in the Mexican population in a center specialized in sarcomas.
Material and Methods: retrospective cohort study from January 1, 2005, to December 31, 2016, 96 patients over 21 years of age with a diagnosis of osteosarcoma were analyzed.
Results: the median time to diagnosis from the onset of symptoms was six months (range: 2-36). This variable was dichotomized by applying the operator-dependent curve (ROC) analysis and we determined a cut-off value greater than five months, with an area under the curve (AUC) = 0.93 [95% CI 0.86-0.97], sensitivity 93.2% and specificity 94.6%.
Conclusion: time until diagnosis is a critical factor in the survival of adult patients with osteosarcoma, highlighting its influence on disease progression and the appearance of metastasis. The correlation between diagnostic delay and an unfavorable prognosis reinforces the need for rapid and efficient evaluation in suspected cases of osteosarcoma.
Databáze: MEDLINE
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