Preservation of naive-phenotype CD4+ T cells after vaccination contributes to durable immunity.

Autor:	Pan YG; Department of Medicine, Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Bartolo L; Department of Medicine, Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Xu R; Department of Medicine, Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA., Patel BV; Department of Medicine, Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA., Zarnitsyna VI; Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA., Su LF; Department of Medicine, Division of Rheumatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, Pennsylvania, USA.
Jazyk:	angličtina
Zdroj:	JCI insight [JCI Insight] 2024 Jun 11; Vol. 9 (14). Date of Electronic Publication: 2024 Jun 11.
DOI:	10.1172/jci.insight.180667
Abstrakt:	Memory T cells are conventionally associated with durable recall responses. In our longitudinal analyses of CD4+ T cell responses to the yellow fever virus (YFV) vaccine by peptide-MHC tetramers, we unexpectedly found CD45RO-CCR7+ virus-specific CD4+ T cells that expanded shortly after vaccination and persisted months to years after immunization. Further phenotypic analyses revealed the presence of stem cell-like memory T cells within this subset. In addition, after vaccination T cells lacking known memory markers and functionally resembling genuine naive T cells were identified, referred to herein as marker-negative T (TMN) cells. Single-cell TCR sequencing detected expanded clonotypes within the TMN subset and identified TMN TCRs shared with memory and effector T cells. Longitudinal tracking of YFV-specific responses over subsequent years revealed superior stability of TMN cells, which correlated with the longevity of the overall tetramer+ population. These findings uncover additional complexity within the post-immune T cell compartment and implicate TMN cells in durable immune responses.
Databáze:	MEDLINE
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