Myeloid sarcoma with plasmacytoid dendritic cell-like proliferation associated with IKZF1, ETV6 and DNMT3A mutations.

Autor: Suzuki K; Department of Hematology, Fukushima Medical University, Fukushima, 960-1295, Japan., Koyama D; Department of Hematology, Fukushima Medical University, Fukushima, 960-1295, Japan. dkoyama@fmu.ac.jp., Oka Y; Department of Diagnostic Pathology, Fukushima Medical University, Fukushima, 960-1295, Japan., Sato Y; Department of Hematology, Fukushima Medical University, Fukushima, 960-1295, Japan., Sekine R; Department of Diagnostic Pathology, Fukushima Medical University, Fukushima, 960-1295, Japan., Fukatsu M; Department of Hematology, Fukushima Medical University, Fukushima, 960-1295, Japan., Hayashi K; Department of Hematology, Fukushima Medical University, Fukushima, 960-1295, Japan., Takano M; Department of Hematology, Fukushima Medical University, Fukushima, 960-1295, Japan., Hashimoto Y; Department of Diagnostic Pathology, Fukushima Medical University, Fukushima, 960-1295, Japan., Ikezoe T; Department of Hematology, Fukushima Medical University, Fukushima, 960-1295, Japan.
Jazyk: angličtina
Zdroj: International journal of hematology [Int J Hematol] 2024 Sep; Vol. 120 (3), pp. 382-388. Date of Electronic Publication: 2024 Jun 11.
DOI: 10.1007/s12185-024-03806-z
Abstrakt: The classification of clonal plasmacytoid dendritic cell (pDC) proliferation associated with myeloid neoplasms remains a topic of ongoing debate. Although the fifth edition of the World Health Organization classification classifies clonal pDC proliferation into two categories, it is unclear whether this classification adequately captures the complexities of clonal pDC pathogenesis. We present a clinical case featuring myeloid sarcoma with pDC-like cells in cervical lymph nodes and bone marrow (BM). Analysis of biopsy specimens and BM aspirate revealed two distinct cellular populations expressing myeloid and pDC markers. One population exhibited myeloid leukemia and monocyte markers, including MPO, CD13, CD33, CD11b, and CD14, while the other manifested an immunophenotype reminiscent of pDCs, characterized by expression of CD56 and CD123. Additionally, whole exome sequencing and RNA sequencing of BM mononuclear cells were conducted to explore the pathophysiology of this rare malignancy, and unveiled pDC-like cell proliferation driven by IKZF1 and ETV6 mutations originating from clonal hematopoiesis initiated by a DNMT3A mutation. Notably, venetoclax-based therapy exhibited efficacy for achieving and sustaining complete remission. This case provides pivotal insights into the mechanistic aspects of pDC/pDC-like cell proliferation in myeloid sarcoma, offering valuable perspectives on therapeutic strategies.
(© 2024. Japanese Society of Hematology.)
Databáze: MEDLINE
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