Fueling the success of transplantation through nutrition: recent insights into nutritional interventions, their interplay with gut microbiota and cellular mechanisms.

Autor:	Koehler FC; Department II of Internal Medicine and Center for Molecular Medicine Cologne.; CECAD Research Center, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Späth MR; Department II of Internal Medicine and Center for Molecular Medicine Cologne.; CECAD Research Center, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany., Meyer AM; Department II of Internal Medicine and Center for Molecular Medicine Cologne., Müller RU; Department II of Internal Medicine and Center for Molecular Medicine Cologne.; CECAD Research Center, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Jazyk:	angličtina
Zdroj:	Current opinion in organ transplantation [Curr Opin Organ Transplant] 2024 Aug 01; Vol. 29 (4), pp. 284-293. Date of Electronic Publication: 2024 Jun 10.
DOI:	10.1097/MOT.0000000000001159
Abstrakt:	Purpose of Review: The role of nutrition in organ health including solid organ transplantation is broadly accepted, but robust data on nutritional regimens remains scarce calling for further investigation of specific dietary approaches at the different stages of organ transplantation. This review gives an update on the latest insights into nutritional interventions highlighting the potential of specific dietary regimens prior to transplantation aiming for organ protection and the interplay between dietary intake and gut microbiota. Recent Findings: Nutrition holds the potential to optimize patients' health prior to and after surgery, it may enhance patients' ability to cope with the procedure-associated stress and it may accelerate their recovery from surgery. Nutrition helps to reduce morbidity and mortality in addition to preserve graft function. In the case of living organ donation, dietary preconditioning strategies promise novel approaches to limit ischemic organ damage during transplantation and to identify the underlying molecular mechanisms of diet-induced organ protection. Functioning gut microbiota are required to limit systemic inflammation and to generate protective metabolites such as short-chain fatty acids or hydrogen sulfide. Summary: Nutritional intervention is a promising therapeutic concept including the pre- and rehabilitation stage in order to improve the recipients' outcome after solid organ transplantation. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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