A current comprehensive role of immune-checkpoint inhibitors in resectable non-small cell lung cancer: A narrative review.

Autor:	Efil SC; Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, TR 06800, Turkey., Bilgin B; Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, TR 06800, Turkey.; Department of Medical Oncology, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, TR 06031, Turkey., Ceylan F; Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, TR 06800, Turkey., Karakaş H; Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, TR 06800, Turkey., Karahan İ; Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, TR 06800, Turkey., Özsan SN; Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, TR 06800, Turkey., Kosku H; Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, TR 06800, Turkey., Yaman Ş; Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, TR 06800, Turkey.; Department of Medical Oncology, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, TR 06031, Turkey., Bülent Akıncı M; Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, TR 06800, Turkey.; Department of Medical Oncology, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, TR 06031, Turkey., Dede DŞ; Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, TR 06800, Turkey.; Department of Medical Oncology, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, TR 06031, Turkey., Yalçın B; Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, TR 06800, Turkey.; Department of Medical Oncology, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, TR 06031, Turkey., Nahit Şendur MA; Department of Medical Oncology, Ankara Bilkent City Hospital, Ankara, TR 06800, Turkey.; Department of Medical Oncology, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, TR 06031, Turkey.
Jazyk:	angličtina
Zdroj:	Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners [J Oncol Pharm Pract] 2024 Oct; Vol. 30 (7), pp. 1214-1239. Date of Electronic Publication: 2024 Jun 11.
DOI:	10.1177/10781552241260864
Abstrakt:	Objective: The objective of this article is to review the efficacy, safety, and evidence for current use and potential future uses of immune-checkpoint inhibitors (ICIs) in the management of resectable non-small cell lung cancer (NSCLC). Data Sources: A literature review was carried out through PubMed to identify completed and ongoing clinical trials evaluating the use, efficacy, and safety of ICIs in the management of resectable NSCLC. Data Summary: To date, four phase 3 trials have emerged that have changed our treatment practice concerning the utilization of ICIs during the adjuvant and neoadjuvant settings. The IMpower010 and KEYNOTE-091 trials examined the application of adjuvant atezolizumab and pembrolizumab, respectively, following surgical resection and adjuvant chemotherapy. In the CheckMate 816 trial, the combination of nivolumab and chemotherapy as a neoadjuvant therapy received approval for patients with resectable NSCLC. Also, for patients with resectable NSCLC, the use of a pembrolizumab and chemotherapy combination as a perioperative therapy received approval based on the results of the KEYNOTE-671 trial. Apart from these trials, there are numerous phase 2 and phase 3 trials, some of which have been published while others are still in progress. Conclusion: Despite the promising outcomes from these trials there remain several unanswered questions. In this review, we will assess clinical trials involving adjuvant, neoadjuvant, and perioperative ICIs, aiming to address the unresolved questions related to these therapeutic approaches. Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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