Pathological findings and differential diagnoses of lymph node diseases in slaughtered cattle in Brazil: A study of 2000 samples.

Autor:	Lopes CEB; Pathology Sector and MULTILAB, Department of Clinic and Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Xavier FG; Laboratório Federal de Defesa Agropecuária (LFDA), Pedro Leopoldo, Minas Gerais, Brazil., Nicolino RR; Pathology Sector and MULTILAB, Department of Clinic and Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Cordeiro LFM; Pathology Sector and MULTILAB, Department of Clinic and Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Rezende LC; Laboratório Federal de Defesa Agropecuária (LFDA), Pedro Leopoldo, Minas Gerais, Brazil., Lopes MC; Pathology Sector and MULTILAB, Department of Clinic and Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Silva DHL; Pathology Sector and MULTILAB, Department of Clinic and Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Fonseca Júnior AA; Laboratório Federal de Defesa Agropecuária (LFDA), Pedro Leopoldo, Minas Gerais, Brazil., Ferreira LR; Laboratório Federal de Defesa Agropecuária (LFDA), Pedro Leopoldo, Minas Gerais, Brazil., Camargos MF; Laboratório Federal de Defesa Agropecuária (LFDA), Pedro Leopoldo, Minas Gerais, Brazil., Soares Filho PM; Laboratório Federal de Defesa Agropecuária (LFDA), Pedro Leopoldo, Minas Gerais, Brazil., Souza ICC; Laboratório Federal de Defesa Agropecuária (LFDA), Pedro Leopoldo, Minas Gerais, Brazil., Ecco R; Pathology Sector and MULTILAB, Department of Clinic and Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Jazyk:	angličtina
Zdroj:	Veterinary pathology [Vet Pathol] 2024 Nov; Vol. 61 (6), pp. 952-964. Date of Electronic Publication: 2024 Jun 11.
DOI:	10.1177/03009858241257908
Abstrakt:	Slaughterhouse inspections play a crucial role in the sanitary control of zoonoses and foodborne diseases. This study aimed to identify and analyze the frequencies of lymph node diseases in cattle slaughtered for human consumption, using the samples sent to the anatomic pathology service of the Federal Laboratory for Agricultural Defense ( Laboratório Federal de Defesa Agropecuária ), Minas Gerais, Brazil, from January 2015 to September 2022. In total, 2000 lymph node samples were analyzed, and additional information was individually retrieved. Lesions were most frequently identified in thoracic lymph nodes. Bacterial isolation and quantitative polymerase chain reaction (qPCR) were performed using samples suspected of tuberculosis. Tuberculosis cases accounted for 89.3% of the samples. Histopathology was more sensitive than other ancillary tests for diagnosing tuberculosis. Paraffin-embedded tissues from lymphoma cases were subjected to immunophenotyping using anti-CD3 and anti-CD79a immunohistochemistry. Frozen and/or paraffin-embedded tissues from lymphoma cases were used to identify the enzootic bovine leukosis (EBL) retrovirus through qPCR. Other diagnoses included primary (T- and B-cell lymphoma) and metastatic neoplasms (squamous cell carcinoma, pulmonary adenocarcinoma, undifferentiated carcinoma, undifferentiated adenocarcinoma, undifferentiated sarcoma, undifferentiated round cell tumor, mesothelioma, hepatic carcinoid, meningioma, and seminoma), actinogranulomas (pyogranulomatous lymphadenitis [actinobacillosis and actinomycosis]), idiopathic lymphadenitis (neutrophilic and/or histiocytic, granulomatous, and suppurative), and miscellaneous nonspecific lymphadenopathies (depletion/lymphoid atrophy, lymphangiectasia, erythrocyte drainage, parasitic eosinophilic lymphadenitis, follicular hyperplasia, and toxic granulomatous lymphadenitis). The combination of histopathology with complementary techniques is important for successful diagnosis, especially in complex cases of high epidemiological, economic, and zoosanitary importance, such as tuberculosis and EBL. Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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