Assessment of Biological Damage Induced during Multidetector Computed Tomography (MDCT) Examination.

Autor: Laad AP; Department of Medical Imaging Technology, K.S. Hegde Medical Academy, Nitte (Deemed to be University), Deralakatte, Mangalore, India., Gnanasekaran TS; Central Research Laboratory, K.S. Hegde Medical Academy, Nitte (Deemed to be University), Deralakatte, Mangalore, India., Shetty SK; Department of Medical Imaging Technology, K.S. Hegde Medical Academy, Nitte (Deemed to be University), Deralakatte, Mangalore, India. shettyshashi.research@gmail.com., Vidyan SK; Department of Medical Imaging Technology, K.S. Hegde Medical Academy, Nitte (Deemed to be University), Deralakatte, Mangalore, India., Chodankar SS; Department of Medical Imaging Technology, K.S. Hegde Medical Academy, Nitte (Deemed to be University), Deralakatte, Mangalore, India., Nalilu SK; Department of Biochemistry, K.S. Hegde Medical Academy, Nitte (Deemed to be University), Deralakatte, Mangalore, India., Radhakrishna V; Central Research Laboratory, K.S. Hegde Medical Academy, Nitte (Deemed to be University), Deralakatte, Mangalore, India. vishakh.kedhilaya@gmail.com.
Jazyk: angličtina
Zdroj: Cell biochemistry and biophysics [Cell Biochem Biophys] 2024 Sep; Vol. 82 (3), pp. 2347-2353. Date of Electronic Publication: 2024 Jun 10.
DOI: 10.1007/s12013-024-01345-2
Abstrakt: Computed tomography (CT) is known for its non-invasiveness, fast procedure, and also for providing detailed diagnostic information to physicians. It also utilises low-dose-rate ionising radiation (X-rays) as a source for imaging. Multidetector computed tomography (MDCT) is an advanced system that uses iodinated contrast media for more accurate diagnostic results. Studies suggest using these contrasts will lead to greater radiation adsorption with significant DNA damage. No studies have been taken comparing the physical dose with the biological effect. The present study sheds light on the same by assessing the biological effect of CT with and without contrast intervention. The present study is timebound; thus, 21 participants attending for CT thorax and abdomen with no history of any cancer were included. The same participants underwent both pre-contrast and post-contrast studies. The blood sample was taken before the procedure and used as a control. Physical parameters like DLP and CTDI obtained from the instrument were compared with the MN frequency obtained (CBMN Assay). The study showed a significant increase (p-value < 0.05) in the Physical and MN frequency in the Post-Contrast group compared to the pre-contrast group. Although a positive correlation was observed between pre and post-contrast groups, the results were not found to be statistically significant (p-value < 0.05). The study confirms increased physical dose and MN frequency upon contrast intervention. This study recommends the judicial use of MDCT in disease diagnostics.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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