Brain network topological changes in inflammatory bowel disease: an exploratory study.

Autor: Polverino A; Institute for Diagnosis and Treatment Hermitage Capodimonte, Naples, Italy., Troisi Lopez E; Institute of Applied Sciences and Intelligent Systems, National Research Council, Pozzuoli, Italy., Minino R; Department of Motor Sciences and Wellness, University of Naples 'Parthenope', Naples, Italy., Romano A; Department of Motor Sciences and Wellness, University of Naples 'Parthenope', Naples, Italy., Miranda A; Hepato-Gastroenterology Unit, University of Campania 'Luigi Vanvitelli', Caserta, Italy., Facchiano A; Gastroenterology and Digestive Endoscopy Unit, Umberto I General Hospital, Nocera Inferiore, Italy., Cipriano L; Department of Motor Sciences and Wellness, University of Naples 'Parthenope', Naples, Italy., Sorrentino P; Institute of Applied Sciences and Intelligent Systems, National Research Council, Pozzuoli, Italy.; Department of Biomedical Sciences, University of Sassari, Sassari, Italy.; Institut de Neurosciences des Systèmes, Aix-Marseille Université, Marseille, France.
Jazyk: angličtina
Zdroj: The European journal of neuroscience [Eur J Neurosci] 2024 Aug; Vol. 60 (4), pp. 4409-4420. Date of Electronic Publication: 2024 Jun 10.
DOI: 10.1111/ejn.16442
Abstrakt: Although the aetio-pathogenesis of inflammatory bowel diseases (IBD) is not entirely clear, the interaction between genetic and adverse environmental factors may induce an intestinal dysbiosis, resulting in chronic inflammation having effects on the large-scale brain network. Here, we hypothesized inflammation-related changes in brain topology of IBD patients, regardless of the clinical form [ulcerative colitis (UC) or Crohn's disease (CD)]. To test this hypothesis, we analysed source-reconstructed magnetoencephalography (MEG) signals in 25 IBD patients (15 males, 10 females; mean age ± SD, 42.28 ± 13.15; mean education ± SD, 14.36 ± 3.58) and 28 healthy controls (HC) (16 males, 12 females; mean age ± SD, 45.18 ± 12.26; mean education ± SD, 16.25 ± 2.59), evaluating the brain topology. The betweenness centrality (BC) of the left hippocampus was higher in patients as compared with controls, in the gamma frequency band. It indicates how much a brain region is involved in the flow of information through the brain network. Furthermore, the comparison among UC, CD and HC showed statistically significant differences between UC and HC and between CD and HC, but not between the two clinical forms. Our results demonstrated that these topological changes were not dependent on the specific clinical form, but due to the inflammatory process itself. Broader future studies involving panels of inflammatory factors and metabolomic analyses on biological samples could help to monitor the brain involvement in IBD and to clarify the clinical impact.
(© 2024 The Author(s). European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: