Bio-Inspired Micro- and Nano-Scale Surface Features Produced by Femtosecond Laser-Texturing Enhance TiZr-Implant Osseointegration.

Autor: Lackington WA; Biointerfaces Lab, Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, 9014, Switzerland., Bellon B; Institut Straumann AG, Basel, 4052, Switzerland.; Faculty of Medicine and Health Technology, University of Tampere, Tampere, 33720, Finland., Guimond S; Biointerfaces Lab, Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, 9014, Switzerland., Schweizer P; Mechanics of Materials & Nanostructures Lab, Empa, Swiss Federal Laboratories for Materials Science and Technology, Thun, 3603, Switzerland., Cancellieri C; Joining Technologies & Corrosion Lab, Empa, Swiss Federal Laboratories for Materials Science and Technology, Dübendorf, 8600, Switzerland., Ambeza A; Laser TSE, GF Machining Solutions SA, Geneva, 1242, Switzerland., Chopard-Lallier AL; Anthogyr SAS, Sallanches, 74700, France., Pippenger B; Institut Straumann AG, Basel, 4052, Switzerland.; Department of Periodontology, University of Bern, Bern, 3010, Switzerland., Armutlulu A; Institut Straumann AG, Basel, 4052, Switzerland., Maeder X; Mechanics of Materials & Nanostructures Lab, Empa, Swiss Federal Laboratories for Materials Science and Technology, Thun, 3603, Switzerland., Schmutz P; Joining Technologies & Corrosion Lab, Empa, Swiss Federal Laboratories for Materials Science and Technology, Dübendorf, 8600, Switzerland., Rottmar M; Biointerfaces Lab, Empa, Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, 9014, Switzerland.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Sep; Vol. 13 (23), pp. e2400810. Date of Electronic Publication: 2024 Jun 21.
DOI: 10.1002/adhm.202400810
Abstrakt: Surface design plays a critical role in determining the integration of dental implants with bone tissue. Femtosecond laser-texturing has emerged as a breakthrough technology offering excellent uniformity and reproducibility in implant surface features. However, when compared to state-of-the-art sandblasted and acid-etched surfaces, laser-textured surface designs typically underperform in terms of osseointegration. This study investigates the capacity of a bio-inspired femtosecond laser-textured surface design to enhance osseointegration compared to state-of-the-art sandblasted & acid-etched surfaces. Laser-texturing facilitates the production of an organized trabeculae-like microarchitecture with superimposed nano-scale laser-induced periodic surface structures on both 2D and 3D samples of titanium-zirconium-alloy. Following a boiling treatment to modify the surface chemistry, improving wettability to a contact angle of 10°, laser-textured surfaces enhance fibrin network formation when in contact with human whole blood, comparable to state-of-the-art surfaces. In vitro experiments demonstrate that laser-textured surfaces significantly outperform state-of-the-art surfaces with a 2.5-fold higher level of mineralization by bone progenitor cells after 28 days of culture. Furthermore, in vivo evaluations reveal superior biomechanical integration of laser-textured surfaces after 28 days of implantation. Notably, during abiological pull-out tests, laser-textured surfaces exhibit comparable performance, suggesting that the observed enhanced osseointegration is primarily driven by the biological response to the surface.
(© 2024 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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