Association between telomere length and anorexia of ageing: a cross-sectional study conducted with community-dwelling older people.

Autor: Vieira RA; Nursing School, Federal University of Alfenas, Alfenas, Brazil., Nunes DP; Nursing School, University of Campinas, Campinas, Brazil., Lima DB; Faculty of Nutrition, Federal University of Alfenas, Alfenas, Brazil., Rocha GDS; Health and Sport Sciences Center, Federal University of Acre, Rio Branco, Brazil., Corona LP; Applied Sciences School, University of Campinas, Campinas, Brazil., Santos-Orlandi AAD; Nursing Department, Federal University of São Carlos, São Carlos, Brazil., Sampaio ES; Faculty of Nutrition, Federal University of Alfenas, Alfenas, Brazil., Rodrigues PCOG; Faculty of Nutrition, Federal University of Alfenas, Alfenas, Brazil., de Brito TRP; Faculty of Nutrition, Federal University of Alfenas, Alfenas, Brazil.
Jazyk: angličtina
Zdroj: Journal of human nutrition and dietetics : the official journal of the British Dietetic Association [J Hum Nutr Diet] 2024 Oct; Vol. 37 (5), pp. 1209-1218. Date of Electronic Publication: 2024 Jun 10.
DOI: 10.1111/jhn.13338
Abstrakt: Background: To verify whether shorter telomere length is associated with anorexia of ageing in community-dwelling older people.
Methods: Conducted as a cross-sectional investigation, the study enrolled 448 participants residing in an urban area of a municipality in Brazil. Relative telomere length in blood samples was measured using quantitative polymerase chain reaction (qPCR), whereas the presence of anorexia of ageing was determined using the Simplified Appetite Nutritional Questionnaire. Data analysis employed multiple logistic regression.
Results: Among the 448 older individuals surveyed, 70.69% were female, and the predominant age bracket ranged from 60 to 69 years (45.08%). Approximately 25% exhibited the shortest telomeric length, with a corresponding anorexia of ageing prevalence of 41.16%. Older individuals with diminished telomere lengths displayed an increased likelihood of experiencing anorexia of ageing (odds ratio [OR] = 1.92; 95% confidence interval [CI] = 1.12-3.29), independent of factors such as gender, age group, depressive symptoms, pain and performance in basic daily life activities.
Conclusions: The observed association between anorexia of ageing and a telomeric biomarker underscores the imperative to meticulously evaluate the nutritional dimensions of older people, with a view to implementing interventions that may enhance their overall health status.
(© 2024 British Dietetic Association.)
Databáze: MEDLINE
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