Outcomes of central nervous system tuberculosis in Saudi Arabia: a multi-center study.

Autor:	Dhafer Alshehri F; Departemnt of Neuroscience, Section of Neurosurgery, King Abdul Aziz Medical City, Ministry of the National Guard Health Affairs, King Abdullah International Medical Research Center, King Abdul Aziz Medical City, Jeddah, Saudi Arabia., Mahmood Okal F; Departemnt of Neuroscience, Section of Neurosurgery, King Abdul Aziz Medical City, Ministry of the National Guard Health Affairs, King Abdullah International Medical Research Center, King Abdul Aziz Medical City, Jeddah, Saudi Arabia., Baeshen SK; Neurosurgery Department, National Neuroscience Institute, King Fahad Medical City, Riyadh, Saudi Arabia., Alharbi ZG; Neurosurgery Department, Al-Noor Specialist Hospital, Makkah, Saudi Arabia., Khojah O; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.; Department of Medicine, Ministry of the National Guard Health Affairs, Jeddah, Saudi Arabia.; Department of Ophthalmology, King Khalid Eye Specialist Hospital, Riyadh, Saudi Arabia., Alhawsawi WK; Department of Dermatology, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia., Alamoudi S; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.; Department of Medicine, Ministry of the National Guard Health Affairs, Jeddah, Saudi Arabia.; Department of Ophthalmology, King Khalid Eye Specialist Hospital, Riyadh, Saudi Arabia.; King Abdullah International Medical Research Center, Jeddah, Saudi Arabia., Bahati A; Neurosurgery Section, Department of Neurosciences, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia., Lary AI; Departemnt of Neuroscience, Section of Neurosurgery, King Abdul Aziz Medical City, Ministry of the National Guard Health Affairs, King Abdullah International Medical Research Center, King Abdul Aziz Medical City, Jeddah, Saudi Arabia.; College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
Jazyk:	angličtina
Zdroj:	Neurological research [Neurol Res] 2024 Sep; Vol. 46 (9), pp. 812-822. Date of Electronic Publication: 2024 Jun 10.
DOI:	10.1080/01616412.2024.2359262
Abstrakt:	Objectives: Central nervous system tuberculosis (TB) (CNS-TB) can occur in several forms, including intracranial tuberculoma, tuberculous brain abscess, TB meningitis (TBM), and spinal TB. Early treatment can save lives and prevent severe neurological complications. This study aimed to describe the characteristics and post-treatment outcomes of patients with CNS-TB and identify factors associated with poor outcomes. To the best of our knowledge, this is the largest CNS-TB study till date published in Saudi Arabia. Methods: This retrospective cohort study included all patients diagnosed with CNS-TB in three tertiary centers in Saudi Arabia (King Abdulaziz Medical City in Jeddah, King Abdulaziz Medical City in Riyadh, and Al-Noor Specialist Hospital in Makkah) between 2009 and 2019. Data of patients' demographics, co-morbidities, presenting symptoms, type of CNS-TB, medical and surgical treatments, and outcome after completion of treatment were obtained from medical records. Treatment outcomes were categorized using the modified Rankin Scale for neurological disability. Results: A total of 140 participants were included in this study from 2009 to 2019. Good outcomes were achieved in approximately 65% of cases, whereas 35% had poor outcomes based on the modified Rankin Scale. Glasgow Coma Scale score ≤10 at presentation and TBM/tuberculoma were significantly associated with poor outcomes. Moreover, the use of corticosteroids, more than three anti-TB medications, and surgical interventions were not significantly associated with good or poor outcomes. Discussion: CNS-TB is associated with a high burden of long-term neurological morbidity. Early detection and treatment are crucial to prevent serious complications and decrease morbidity and mortality.
Databáze:	MEDLINE
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