Refining the hospitalization rate: A mixed methods approach to differentiate primary COVID-19 from incidental cases.

Autor:	Misailovski M; Department of Infectious Control and Infectious Diseases, University Medical Center Göttingen, Göttingen, Germany., Koller D; Institute of Medical Data Processing, Biometrics and Epidemiology, Faculty of Medicine, LMU Munich, Munich, Germany., Blaschke S; Emergency Department, University Medical Center Göttingen, 37075 Göttingen, Germany., Berens M; Department of Infectious Control and Infectious Diseases, University Medical Center Göttingen, Göttingen, Germany., Köster AM; Department of Infectious Control and Infectious Diseases, University Medical Center Göttingen, Göttingen, Germany., Strobl R; Institute of Medical Data Processing, Biometrics and Epidemiology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Center for Vertigo and Balance Disorders, Faculty of Medicine, University Hospital, LMU Munich, Munich, Germany., Berner R; Department of Pediatrics, University Hospital and Medical Faculty Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany., Boor P; Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany., Eisenmann M; Infection Control and Antimicrobial Stewardship Unit, University Hospital Wuerzburg, Wuerzburg, Germany., von Stillfried S; Institute of Pathology, RWTH Aachen University Hospital, Aachen, Germany., Krefting D; Department of Medical Informatics, University Medical Center Göttingen, Göttingen, Germany., Krone M; Infection Control and Antimicrobial Stewardship Unit, University Hospital Wuerzburg, Wuerzburg, Germany., Liese J; Department of Paediatrics, University Hospital Wuerzburg, Wuerzburg, Germany., Meybohm P; University Hospital Würzburg, Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, Würzburg, Germany., Ulrich-Merzenich G; Synergy Research and Experimental Medicine Lab, Medical Clinic III, University Hospital Bonn, Bonn, Germany.; Staff Unit for Scientific & Medical Technology Development & Coordination (MWTek), Commercial Directorate, University Hospital Bonn, Bonn, Germany., Zenker S; Staff Unit for Scientific & Medical Technology Development & Coordination (MWTek), Commercial Directorate, University Hospital Bonn, Bonn, Germany.; Applied Medical Informatics (AMI) Lab, Institute for Medical Biometry, Informatics & Epidemiology (IMBIE), University Hospital Bonn, Bonn, Germany.; Applied Mathematical Physiology (AMP) Lab, Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany., Scheithauer S; Department of Infectious Control and Infectious Diseases, University Medical Center Göttingen, Göttingen, Germany., Grill E; Institute of Medical Data Processing, Biometrics and Epidemiology, Faculty of Medicine, LMU Munich, Munich, Germany.; German Center for Vertigo and Balance Disorders, Faculty of Medicine, University Hospital, LMU Munich, Munich, Germany.
Jazyk:	angličtina
Zdroj:	Infection prevention in practice [Infect Prev Pract] 2024 May 15; Vol. 6 (3), pp. 100371. Date of Electronic Publication: 2024 May 15 (Print Publication: 2024).
DOI:	10.1016/j.infpip.2024.100371
Abstrakt:	Purpose: Until now, the Hospitalization Rate (HR) served as an indicator (among others) for the COVID-19 associated healthcare burden. To ensure that the HR accomplishes its full potential, hospitalizations caused by COVID-19 (primary cases) and hospitalizations of patients with incidental positive SARS-CoV-2 test results (incidental cases) must be differentiated. The aim of this study was to synthesize the existing evidence on differentiation criteria between hospitalizations of primary cases and incidental cases. Methods: An online survey of the members of the German Network University Medicine (NUM) was conducted. Additionally, senior clinicians with expertise in COVID-19 care were invited for qualitative, semi-structured interviews. Furthermore, a rapid literature review was undertaken on publications between 03/2020 and 12/2022. Results: In the online survey (n=30, response rate 56%), pneumonia and acute upper respiratory tract infections were the most indicative diagnoses for a primary case. In contrast, malignant neoplasms and acute myocardial infarctions were most likely to be associated with incidental cases. According to the experts (n=6), the diagnosis, ward, and type of admission (emergency or elective), low oxygen saturation, need for supplemental oxygen, and initiation of COVID-19 therapy point to a primary case. The literature review found that respiratory syndromes and symptoms, oxygen support, and elevated levels of inflammatory markers were associated with primary cases. Conclusion: There are parameters for the differentiation of primary from incidental cases to improve the objective of the HR. Ultimately, an updated HR has the potential to serve as a more accurate indicator of the COVID-19 associated healthcare burden. (© 2024 The Authors.)
Databáze:	MEDLINE
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