Seven tesla knee MRI T2*-mapping detects intrasubstance meniscus degeneration in patients with posterior root tears.

Autor:	Kajabi AW; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, 55455, United States.; Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, United States., Zbýň Š; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, 55455, United States.; Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, United States.; Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44196, United States., Smith JS; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, 55455, United States.; Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, United States.; Diagnostic Radiology, Oregon Health & Science University, Portland, OR, 97239, United States., Hedayati E; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, 55455, United States.; Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, United States., Knutsen K; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, 55455, United States.; Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, United States., Tollefson LV; Twin Cities Orthopedics, Edina, MN, 55435, United States., Homan M; Twin Cities Orthopedics, Edina, MN, 55435, United States., Abbasguliyev H; Department of Diagnostic and Interventional Radiology, Ataturk University Research Hospital, Erzurum, 25240, Türkiye., Takahashi T; Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, United States., Metzger GJ; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, 55455, United States., LaPrade RF; Twin Cities Orthopedics, Edina, MN, 55435, United States., Ellermann JM; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, 55455, United States.; Department of Radiology, University of Minnesota, Minneapolis, MN, 55455, United States.
Jazyk:	angličtina
Zdroj:	Radiology advances [Radiol Adv] 2024 Mar 19; Vol. 1 (1), pp. umae005. Date of Electronic Publication: 2024 Mar 19 (Print Publication: 2024).
DOI:	10.1093/radadv/umae005
Abstrakt:	Background: Medial meniscus root tears often lead to knee osteoarthritis. The extent of meniscal tissue changes beyond the localized root tear is unknown. Purpose: To evaluate if 7 Tesla 3D T2*-mapping can detect intrasubstance meniscal degeneration in patients with arthroscopically verified medial meniscus posterior root tears (MMPRTs), and assess if tissue changes extend beyond the immediate site of the posterior root tear detected on surface examination by arthroscopy. Methods: In this prospective study we acquired 7 T knee MRIs from patients with MMPRTs and asymptomatic controls. Using a linear mixed model, we compared T2* values between patients and controls, and across different meniscal regions. Patients underwent arthroscopic assessment before MMPRT repair. Changes in pain levels before and after repair were calculated using Knee Injury & Osteoarthritis Outcome Score (KOOS). Pain changes and meniscal extrusion were correlated with T2* using Pearson correlation ( r ). Results: Twenty patients (mean age 53 ± 8; 16 females) demonstrated significantly higher T2* values across the medial meniscus (anterior horn, posterior body and posterior horn: all P  <   .001; anterior body: P  =   .007), and lateral meniscus anterior ( P  =   .024) and posterior ( P  <   .001) horns when compared to the corresponding regions in ten matched controls (mean age 53 ± 12; 8 females). Elevated T2* values were inversely correlated with the change in pain levels before and after repair. All patients had medial meniscal extrusion of ≥2 mm. Arthroscopy did not reveal surface abnormalities in 70% of patients (14 out of 20). Conclusions: Elevated T2* values across both medial and lateral menisci indicate that degenerative changes in patients with MMPRTs extend beyond the immediate vicinity of the posterior root tear. This suggests more widespread meniscal degeneration, often undetected by surface examinations in arthroscopy. Competing Interests: Please see ICMJE form(s) for author conflicts of interest. These have been provided as supplementary materials. RFL reports a relationship with Ossur and Smith and Nephew that includes consulting or advisory, funding grants and travel reimbursement; Arthroscopy Association of North America (AANA) and American Orthopaedic Society for Sports Medicine (AOSSM) that includes funding grants; and royalties paid to Ossur, Smith and Nephew, and Elsevier. All other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this study. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Radiological Society of North America.)
Databáze:	MEDLINE
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