Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China: A national multicenter survey of 35,566 individuals.

Autor: Liu MF; Graduate School of Beijing University of Chinese Medicine Beijing China.; Department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship Hospital Beijing China., Ma RX; Department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of Yinchuan Yinchuan China., Cao XB; Department of Otorhinolaryngology The First People's Hospital of Yunnan Province Kunming China., Zhang H; Department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical University Urumqi China., Zhou SH; Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China., Jiang WH; Department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South University Changsha China., Jiang Y; Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao University Qingdao China., Sun JW; Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTC Hefei China., Yang QT; Department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen University Guangzhou China., Li XZ; Department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong University Jinan China., Sun YN; Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical University Harbin China., Shi L; Department of Otolaryngology, The Second Hospital of Shandong University Shandong University Jinan China., Wang M; Department of Otorhinolaryngology Head and Neck Surgery Peking University People's Hospital Beijing China., Song XC; Department of Otorhinolaryngology Head and Neck Surgery, Yantai Yuhuangding Hospital Qingdao University Yantai China., Chen FQ; Department of Otorhinolaryngology Head and Neck Surgery, Xijing Hospital The Fourth Military Medical University Xi'an China., Zhang XS; Gansu Provincial Center for Disease Control and Prevention Lanzhou China., Wei HQ; Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical University Shenyang China., Yu SQ; Department of Otorhinolaryngology Head and Neck Surgery, Tongji Hospital Tongji Medical University Shanghai China., Zhu DD; Department of Otorhinolaryngology Head and Neck Surgery China-Japan Union Hospital of Jilin University Changchun China., Ba L; Department of Otorhinolaryngology Head and Neck Surgery Xizang Autonomous Region People's Hospital Lasa China., Cao ZW; Department of Otorhinolaryngology Head and Neck Surgery Shengjing Hospital of China Medical University Shenyang China., Xiao XP; Department of Otorhinolaryngology Head and Neck Surgery Hunan Provincial People's Hospital Changsha China., Wei X; Department of Otorhinolaryngology Head and Neck Surgery Hainan General Hospital Haikou China., Lin ZH; Department of Otorhinolaryngology Head and Neck Surgery, The Second Affiliated Hospital, College of Medicine Zhejiang University Hangzhou China., Chen FH; Department of Otorhinolaryngology, The First Affiliated Hospital Sun Yat-sen University Guangzhou China., Shan CG; Department of Otorhinolaryngology Head and Neck Surgery The Second Hospital of Hebei Medical University Shijiazhuang China., Wang GK; Department of Otorhinolaryngology Head and Neck Surgery Henan Provincial People's Hospital Zhengzhou China., Ye J; Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Nanchang University Nanchang China., Qu SH; Department of Otorhinolaryngology Head and Neck Surgery Guangxi Zhuang Autonomous Region People's Hospital Nanning China., Zhao CQ; Department of Otorhinolaryngology Head and Neck Surgery Shanxi Medical University Affiliated Second Hospital Taiyuan China., Wang ZL; Department of Otorhinolaryngology Head and Neck Surgery, XuanWu Hospital Capital Medical University Beijing China., Li HB; Department of Otorhinolaryngology Head and Neck Surgery, Eye, Ear, Nose and Throat Hospital, Shanghai Medical College Fudan University Shanghai China., Liu F; Department of Otorhinolaryngology Head and Neck Surgery, West China Hospital Sichuan University Chengdu China., Cui XB; Department of Otorhinolaryngology Head and Neck Surgery Affiliated Hospital of Inner Mongolia Medical University Hohhot China., Ye SN; Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical University Fuzhou China., Liu Z; Department of Otorhinolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China., Xu Y; Department of Otorhinolaryngology Head and Neck Surgery Renmin Hospital of Wuhan University Wuhan China., Cai X; Department of Otorhinolaryngology Head and Neck Surgery Qinghai Provincial People's Hospital Xining China., Huang W; Department of Otorhinolaryngology Head and Neck Surgery Tianjin Huanhu Hospital Tianjin China., Zhang RX; Department of Otorhinolaryngology Head and Neck Surgery Huadong Hospital Affiliated to Fudan University Shanghai China., Zhao YL; Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou China., Yu GD; Department of Otorhinolaryngology Head and Neck Surgery Affiliated Hospital of Guizhou Medical University Guiyang China., Shi GG; Department of Otorhinolaryngology Head and Neck Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan China., Lu MP; Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital Nanjing Medical University Nanjing China., Shen Y; Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Chongqing Medical University Chongqing China., Zhao YT; Department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of Yinchuan Yinchuan China., Pei JH; Department of Otorhinolaryngology The First People's Hospital of Yunnan Province Kunming China., Xie SB; Department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South University Changsha China., Yu LG; Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao University Qingdao China., Liu YH; Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Anhui Medical University Hefei China., Gu SW; Department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong University Jinan China., Yang YC; Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Chongqing Medical University Chongqing China., Cheng L; Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital Nanjing Medical University Nanjing China., Liu JF; Department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship Hospital Beijing China.
Jazyk: angličtina
Zdroj: World journal of otorhinolaryngology - head and neck surgery [World J Otorhinolaryngol Head Neck Surg] 2024 Mar 28; Vol. 10 (2), pp. 113-120. Date of Electronic Publication: 2024 Mar 28 (Print Publication: 2024).
DOI: 10.1002/wjo2.167
Abstrakt: Objective: This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in China.
Methods: This study was conducted by 45 tertiary Grade-A hospitals in China. Online and offline questionnaire data were obtained from patients infected with COVID-19 between December 28, 2022, and February 21, 2023. The collected information included basic demographics, medical history, smoking and drinking history, vaccination history, changes in olfactory and gustatory functions before and after infection, and other postinfection symptoms, as well as the duration and improvement status of olfactory and gustatory disorders.
Results: Complete questionnaires were obtained from 35,566 subjects. The overall incidence of olfactory and taste dysfunction was 67.75%. Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste dysfunction. Having received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such dysfunction. Before infection, the average olfactory and taste VAS scores were 8.41 and 8.51, respectively; after infection, they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the survey. The median duration of dysosmia and dysgeusia was 15 and 12 days, respectively, with 0.5% of patients having symptoms lasting for more than 28 days. The overall self-reported improvement rate was 59.16%. Recovery was higher in males, never smokers, those who received two or three vaccine doses, and those that had never experienced dental health issues, or chronic accompanying symptoms.
Conclusions: The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in China. Incidence and prognosis are influenced by several factors, including sex, SARS-CoV-2 vaccination, history of head-facial trauma, nasal and oral health status, smoking and drinking history, and the persistence of accompanying symptoms.
Competing Interests: Professor Lei Cheng, Hua‐Bin Li, Jian‐Feng Liu, Zhen‐Lin Wang, Chang‐Qing Zhao and Dong‐Dong Zhu are the members of World Journal of Otorhinolaryngology ‐ Head and Neck Surgery editorial board and are not involved in the peer review process of this article. The other authors declare no conflict of interest.
(© 2024 The Authors. World Journal of Otorhinolaryngology ‐ Head and Neck Surgery published by John Wiley & Sons Ltd on behalf of Chinese Medical Association.)
Databáze: MEDLINE
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