Effect of sustained decreases in sedentary time and increases in physical activity on liver enzymes and indices in type 2 diabetes.

Autor:	Haxhi J; Department of Clinical and Molecular Medicine, University of Rome La Sapienza, Rome, Italy.; Diabetes Unit, Sant'Andrea University Hospital, Rome, Italy.; Metabolic Fitness Association, Rome, Italy., Vitale M; Department of Clinical and Molecular Medicine, University of Rome La Sapienza, Rome, Italy.; Diabetes Unit, Sant'Andrea University Hospital, Rome, Italy., Mattia L; Department of Clinical and Molecular Medicine, University of Rome La Sapienza, Rome, Italy.; Diabetes Unit, Sant'Andrea University Hospital, Rome, Italy., Giuliani C; Department of Clinical and Molecular Medicine, University of Rome La Sapienza, Rome, Italy.; Diabetes Unit, Sant'Andrea University Hospital, Rome, Italy., Sacchetti M; Department of Human Movement and Sport Sciences, University of Rome 'Foro Italico', Rome, Italy., Orlando G; Department of Human Movement and Sport Sciences, University of Rome 'Foro Italico', Rome, Italy.; Research Centre for Musculoskeletal Science and Sports Medicine, Department of Life Sciences, Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, United Kingdom., Iacobini C; Department of Clinical and Molecular Medicine, University of Rome La Sapienza, Rome, Italy., Menini S; Department of Clinical and Molecular Medicine, University of Rome La Sapienza, Rome, Italy., Zanuso S; Center for Applied Biological and Exercise Sciences, Faculty of Health and Life Sciences, Coventry University, Coventry, United Kingdom.; Centre for Human Performance and Sport, University of Greenwich, London, United Kingdom., Nicolucci A; Center for Outcomes Research and Clinical Epidemiology (CORESEARCH), Pescara, Italy.; Department of Clinical Pharmacology and Epidemiology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Italy., Balducci S; Department of Clinical and Molecular Medicine, University of Rome La Sapienza, Rome, Italy.; Diabetes Unit, Sant'Andrea University Hospital, Rome, Italy.; Metabolic Fitness Association, Rome, Italy., Pugliese G; Department of Clinical and Molecular Medicine, University of Rome La Sapienza, Rome, Italy.; Diabetes Unit, Sant'Andrea University Hospital, Rome, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2024 May 24; Vol. 15, pp. 1393859. Date of Electronic Publication: 2024 May 24 (Print Publication: 2024).
DOI:	10.3389/fendo.2024.1393859
Abstrakt:	Background: Current guidelines for nonalcoholic fatty liver disease (NAFLD) recommend high volumes and/or intensities of physical activity (PA), the achievement of which generally requires participation in supervised exercise training programs that however are difficult to implement in routine clinical practice. Conversely, counselling interventions may be more suitable, but result in only modest increases in moderate-to-vigorous-intensity PA (MVPA). This study assessed whether a counseling intervention for increasing PA and decreasing sedentary time (SED-time) is effective in improving NAFLD markers in people with type 2 diabetes. Methods: Three-hundred physically inactive and sedentary patients were randomized 1:1 to receive one-month theoretical and practical counseling once-a-year (intervention group) or standard care (control group) for 3 years. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyltranspeptidase (γGT) levels were measured and fatty liver index (FLI), hepatic steatosis index (HSI), and visceral adiposity index (VAI) were calculated. Total PA volume, light-intensity PA (LPA), moderate-to-vigorous-intensity PA (MVPA), and SED-time were objectively measured by an accelerometer. Results: Throughout the 3-year period, NAFLD markers did not change in the control group, whereas ALT, γGT, FLI, and HSI decreased in the intervention group, with significant between-group differences, despite modest MVPA increases, which however were associated with larger decrements in SED-time and reciprocal increments in LPA. Mean changes in NAFLD markers varied according to quartiles of (and correlated with) changes in MVPA (all markers) and SED-time, LPA, and PA volume (ALT, γGT, and HSI). Mean changes in MVPA or PA volume were independent predictors of changes in NAFLD markers. When included in the models, change in cardiorespiratory fitness and lower body muscle strength were independently associated with some NAFLD markers. Conclusion: A behavior change involving all domains of PA lifestyle, even if insufficient to achieve the recommended MVPA target, may provide beneficial effects on NAFLD markers in people with type 2 diabetes. Competing Interests: SZ is an employee of Technogym. AN reported grant from Artsana, Astra-Zeneca, Eli Lilly, Novo Nordisk, and Sanofi Aventis and personal fees from Eli Lilly and Novo Nordisk. SB reported personal fees from Astra-Zeneca, Eli Lilly, Novo Nordisk, and Takeda. GP reported personal fees from Astra-Zeneca, Boehringer Ingelheim, Eli Lilly, Merck Sharp & Dome, Mylan, Sigma-Tau, and Takeda. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Haxhi, Vitale, Mattia, Giuliani, Sacchetti, Orlando, Iacobini, Menini, Zanuso, Nicolucci, Balducci and Pugliese.)
Databáze:	MEDLINE
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