Risk Factor Predictors for Developing Epilepsy in Cerebral Palsy Patients in a Tertiary Hospital in Saudi Arabia: A Retrospective Study.

Autor:	Alyoubi R; Neurology, King Abdulaziz University Hospital, Jeddah, SAU., Mirza A; Faculty of Medicine, King Abdulaziz University, Jeddah, SAU., Busaleh F; Pediatrics, Maternity and Children Hospital (MCH), Al-Ahsa, SAU., Ashgar OW; Pediatric Neurology, Faculty of Medicine, King Abdulaziz University, Jeddah, SAU., Alamoudi AA; College of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, SAU., Alnoiqy AM; Faculty of Medicine, King Abdulaziz University, Jeddah, SAU., Alghamdi FA; Faculty of Medicine, King Abdulaziz University, Jeddah, SAU., AlGhamdi MA; College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, SAU., Mazi A; Pediatrics, King Abdulaziz University Hospital, Jeddah, SAU.; Pediatrics, King Abdulaziz University, Jeddah, SAU., Alyahyawi H; Psychiatry, King Abdulaziz University Hospital, Jeddah, SAU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 May 09; Vol. 16 (5), pp. e59980. Date of Electronic Publication: 2024 May 09 (Print Publication: 2024).
DOI:	10.7759/cureus.59980
Abstrakt:	Background Cerebral palsy (CP) is a major cause of childhood motor impairment worldwide. The prevalence of CP related to preterm births has increased consistently. Perinatal hypoxic-ischemic encephalopathy, intra- or periventricular haemorrhage, cerebral dysgenesis and intracranial infections are among the factors contributing to CP onset. Several studies have explored epilepsy-related morbidity among children with CP, finding notable correlations between the two conditions. Worldwide, there are multiple studies highlighting the high prevalence of epilepsy among children with CP and its association with specific CP subtypes and neurologic insults. However, research on the risk factors for epilepsy in CP children is limited, particularly in the Middle East and Saudi Arabia. Aim This study aims to address this gap by analysing potential prenatal, antenatal, and postnatal risk factors associated with epilepsy development in children with CP. Methods A retrospective cohort analysis of 152 children aged 1-14 years diagnosed with CP at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, was conducted. Results The study showed a significant prevalence of epilepsy (68.4%), with generalised seizures being the most common type. Quadriplegia was notably common among CP children with epilepsy, indicating a potential correlation between motor impairment severity and epilepsy risk. Furthermore, CP children with epilepsy exhibited a higher prevalence of co-morbidities, emphasising the multifaceted nature of this condition. Perinatal and neonatal factors, such as hypoxic events, mechanical ventilation, perinatal asphyxia, neonatal convulsions, and microcephaly, were identified as significant risk factors for epilepsy in children with CP. While speech and hearing disorders were present in CP children with and without epilepsy, a slightly higher prevalence of impaired speech was observed in those with epilepsy. However, the difference between the two groups was not significant. Conclusion This study provides valuable insights into the epidemiology, clinical characteristics and potential risk factors associated with epilepsy among children diagnosed with CP in Saudi Arabia. The findings underscore the complexity of managing epilepsy in this population and highlight the need for further research to elucidate the underlying mechanisms and support the development of targeted interventions to improve patient outcomes. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2024, Alyoubi et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu