Neuropsychological and social predictors of participation in a deep brain stimulation study of Parkinson's disease and dystonia.
| Autor: | Hahn A; University of California, San Francisco, Department of Neurological Surgery., Lazar AA; University of California, San Francisco, Department of Epidemiology and Biostatistics., Cernera S; University of California, San Francisco, Department of Neurological Surgery., Little S; University of California, San Francisco, Department of Neurology., Wang SS; University of California, San Francisco, Department of Neurology., Starr PA; University of California, San Francisco, Department of Neurological Surgery., Racine CA; University of California, San Francisco, Department of Neurological Surgery. |
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| Jazyk: | angličtina |
| Zdroj: | MedRxiv : the preprint server for health sciences [medRxiv] 2024 May 31. Date of Electronic Publication: 2024 May 31. |
| DOI: | 10.1101/2024.05.29.24308133 |
| Abstrakt: | Objectives: Participation is essential to DBS research, yet circumstances that affect diverse participation remain unclear. Here we evaluate factors impacting participation in an adaptive DBS study of Parkinson's disease (PD) and dystonia. Methods: Twenty participants were implanted with a sensing-enabled DBS device (Medtronic Summit RC+S) that allows neural data streaming in naturalistic settings and encouraged to stream as much as possible for the first five months after surgery. Using standardized baseline data obtained through neuropsychological evaluation, we compared neuropsychological and social variables to streaming hours. Results: Marital status and irritability significantly impacted streaming hours (estimate=136.7, bootstrapped ( b ) CI b =45.0 to 249.0, p b =0.016, and estimate=-95.1, CI b =-159.9 to -49.2, p b =0.027, respectively). These variables remained significant after multivariable analysis. Composite scores on verbal memory evaluations predicted the number of hours of data streamed ( R 2 =0.284, estimate=67.7, CI b =20.1 to 119.9, p b =0.019). Discussion: Verbal memory impairment, irritability, and lack of a caregiver may be associated with decreased participation. Further study of factors that impact research participation is critical to the sustained inclusion of diverse participants. Competing Interests: Conflict of Interest Statement: Nothing to declare. |
| Databáze: | MEDLINE |
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