Prognostic utility of the geriatric nutritional risk index for head and neck cancer: Systematic review and meta-analysis.

Autor: Tsai YT; Department of Otorhinolaryngology - Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Kuo LT; College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Division of Sports Medicine, Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan., Wang YT; Department of Otorhinolaryngology - Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan., De Vito A; Ear Nose Throat (ENT) Unit, Department of Surgery, Forlì Hospital Health Local Agency of Romagna, Forlì, Italy., Hao SP; Department of Otolaryngology - Head and Neck Surgery, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan., Fang KH; College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Department of Otorhinolaryngology - Head and Neck Surgery, Chang Gung Memorial Hospital, Taoyuan, Taiwan., Lee YC; College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Department of Otorhinolaryngology - Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan., Chen KY; School of Dentistry, National Yang Ming University, Taipei, Taiwan., Lai CH; College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Department of Radiation Oncology, Chang Gung Memorial Hospital, Chiayi, Taiwan., Tsai YH; College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi, Taiwan., Huang EI; Department of Otorhinolaryngology - Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Tsai MS; Department of Otorhinolaryngology - Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Hsu CM; Department of Otorhinolaryngology - Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Chang GH; Department of Otorhinolaryngology - Head and Neck Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.; College of Medicine, Chang Gung University, Taoyuan, Taiwan., Luan CW; College of Medicine, Chang Gung University, Taoyuan, Taiwan.; Lunghwa University of Science and Technology, Taoyuan, Taiwan.; Department of Otorhinolaryngology - Head and Neck Surgery, LO-Sheng Hospital Ministry of Health and Welfare-Home, New Taipei City, Taiwan.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2024 Aug; Vol. 46 (8), pp. 2086-2097. Date of Electronic Publication: 2024 Jun 09.
DOI: 10.1002/hed.27842
Abstrakt: We conducted a systematic review of the literature to assess the potential prognostic utility of geriatric nutritional risk index (GNRI) for head and neck cancer (HNC). We selected studies and extracted data after searching the Cochrane Library, EMBASE, and PubMed databases. The associations between GNRI and survival outcomes were explored by calculating hazard ratios (HRs) and 95% confidence intervals (CIs) through a random-effects meta-analysis. We included 11 studies that involved 2887 patients with HNC. The combined HR demonstrated significant associations of low GNRI with unfavorable progression-free survival (HR = 1.87, 95% CI = 1.32-2.65, p < 0.001) and overall survival (HR = 3.04, 95% CI = 2.30-4.03, p < 0.001). The association between the GNRI and overall survival persisted across various subgroups. The GNRI could serve as a valuable prognostic biomarker for patients with HNC. Low GNRI scores are significantly associated with unfavorable survival outcomes.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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