Four new sesquiterpenoids from the aerial parts of Pogostemon cablin (Blanco.) Benth. and their hypoglycemic activity.

Autor: Liang P; School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, PR China., Peng X; School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, PR China., Hu G; School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, PR China., Wu R; School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, PR China., Jin J; School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, PR China., Ang S; School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, PR China; International Healthcare Innovation Institute (Jiangmen), Jiangmen 529040, PR China. Electronic address: jnuangsong@126.com., Li D; School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529020, PR China; International Healthcare Innovation Institute (Jiangmen), Jiangmen 529040, PR China. Electronic address: wyuchemldl@126.com.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2024 Sep; Vol. 177, pp. 106054. Date of Electronic Publication: 2024 Jun 08.
DOI: 10.1016/j.fitote.2024.106054
Abstrakt: Four previously undescribed sesquiterpenoids (1-4), including two natural guaiane-type sesquiterpenoids (1-2), a rearranged guaiane-type sesquiterpenoid (3), and a norsesquiterpenoid (4), were isolated from the ethanol extract of the aerial parts of Pogostemon cablin (Blanco.) Benth. Their chemical structures were determined based on extensive spectroscopic data analysis, including UV, IR, NMR, HRESIMS, and CD spectroscopy. Compound 1 exhibited a good hypoglycemic activity with glucose uptake of 124.3% and 131.2% in myotubes, respectively, at the concentrations of 20 and 40 μM and showed no cytotoxicity. These findings provide a material basis for further research on P. cablin.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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