Multimodal neuroimaging fusion unravel structural-functional-neurotransmitter change in Parkinson's disease with impulse control disorders.

Autor: Gan C; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China., Cao X; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China., Sun H; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China., Ye S; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China., Shi J; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China., Shan A; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China., Gao M; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China., Wan C; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China., Zhang K; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Electronic address: kezhong_zhang1969@126.com., Yuan Y; Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; Jiangsu Key Laboratory of Neurodegeneration, Nanjing Medical University, Nanjing 211166, China. Electronic address: da_sheng@126.com.
Jazyk: angličtina
Zdroj: Neurobiology of disease [Neurobiol Dis] 2024 Aug; Vol. 198, pp. 106560. Date of Electronic Publication: 2024 Jun 07.
DOI: 10.1016/j.nbd.2024.106560
Abstrakt: Background: Impulse control disorders (ICD) in Parkinson's disease (PD) is highly multifactorial in etiology and has intricate neural mechanisms. Our multimodal neuroimaging study aimed to investigate the specific patterns of structure-function-neurotransmitter interactions underlying ICD.
Methods: Thirty PD patients with ICD (PD-ICD), 30 without ICD (PD-NICD) and 32 healthy controls (HCs) were recruited. Gyrification and perivascular spaces (PVS) were computed to capture the alternations of cortical surface morphology and glymphatic function. Seed-based functional connectivity (FC) were performed to identify the corresponding functional changes. Further, JuSpace toolbox were employed for cross-modal correlations to evaluate whether the spatial patterns of functional alterations in ICD patients were associated with specific neurotransmitter system.
Results: Compared to PD-NICD, PD-ICD patients showed hypogyrification and enlarged PVS volume fraction in the left orbitofrontal gyrus (OFG), as well as decreased FC between interhemispheric OFG. The interhemispheric OFG connectivity reduction was associated with spatial distribution of μ-opioid pathway (r = -0.186, p = 0.029, false discovery rate corrected). ICD severity was positively associated with the PVS volume fraction of left OFG (r = 0.422, p = 0.032). Furthermore, gyrification index (LGI) and percent PVS (pPVS) in OFG and their combined indicator showed good performance in differentiating PD-ICD from PD-NICD.
Conclusions: Our findings indicated that the co-altered structure-function-neurotransmitter interactions of OFG might be involved in the pathogenesis of ICD.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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