Study on the fabrication and controlled release behavior of N-Acetylneuraminic acid-loaded hydrogels stabilized by gelatin/whey protein isolate.

Autor: Xu L; School of Food and Bioengineering, Hefei University of Technology, Hefei 230009, PR China., Wang Y; School of Food and Bioengineering, Hefei University of Technology, Hefei 230009, PR China., Chen X; Institute of Plasma Physics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, PR China., Cao L; School of Food and Bioengineering, Hefei University of Technology, Hefei 230009, PR China; Key Laboratory for Agricultural Products Processing of Anhui Province, Hefei 230009, PR China. Electronic address: Lilycao504@hfut.edu.cn., Pang M; School of Food and Bioengineering, Hefei University of Technology, Hefei 230009, PR China; Key Laboratory for Agricultural Products Processing of Anhui Province, Hefei 230009, PR China. Electronic address: pangmin@hfut.edu.cn.
Jazyk: angličtina
Zdroj: Food chemistry [Food Chem] 2024 Oct 30; Vol. 456, pp. 139934. Date of Electronic Publication: 2024 Jun 05.
DOI: 10.1016/j.foodchem.2024.139934
Abstrakt: Gelatin (GEL), pectin (PEC), carboxymethyl cellulose (CMC), and whey protein isolate (WPI) were employed to formulate hydrogels for stabilizing N-Acetylneuraminic Acid (NeuAc). GEL/WPI-NeuAc hydrogels, irrespective of the ratio, exhibited a flexible and smooth surface with a continuous three-dimensional network structure internally. Porosity of the three types of hydrogels increased from 3.69% to 86.92% (GEL/WPI), 41.67% (PEC/WPI), and 87.62% (CMC/WPI), rendering them suitable as carriers for NeuAc encapsulation. The dynamic swelling behavior of all hydrogels followed Schott's second-order kinetics model. The degradation performance of GEL, PEC, and CMC/WPI-NeuAc hydrogels was optimal at a 5: 5 ratio, with degradation rates of 80.39 ± 1.26%, 82.38 ± 1.96%, and 81.39 ± 1.57%, respectively. GEL, PEC, CMC/WPI-NeuAc hydrogels demonstrated decreased release rates of 44.56%, 31.04%, and 41.26%, respectively, compared to free NeuAc, post gastric digestion. The present investigation suggests the potential of GEL/WPI hydrogels as effective carriers for delivering NeuAc encapsulation.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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