Thyroglobulin specific IgE and a possible link to suspected penicillin induced allergic skin manifestations - cross sectional study.

Autor: Trivić T; Institute of Virology, Vaccines and Sera, Torlak, Vojvode Stepe 458, 11000, Belgrade, Serbia; Department of Immunobiology, University of Lausanne, Switzerland., Blagojević G; Institute of Virology, Vaccines and Sera, Torlak, Vojvode Stepe 458, 11000, Belgrade, Serbia., Živančević-Simonović S; University of Kragujevac, Faculty of Medical Sciences, Department of Pathophysiology, Svetozara Markovića 69, 34000, Kragujevac, Serbia., Janjušević A; Institute of Virology, Vaccines and Sera, Torlak, Vojvode Stepe 458, 11000, Belgrade, Serbia., Dragačević L; Institute of Virology, Vaccines and Sera, Torlak, Vojvode Stepe 458, 11000, Belgrade, Serbia., Burazer L; Institute of Virology, Vaccines and Sera, Torlak, Vojvode Stepe 458, 11000, Belgrade, Serbia., Prodić I; Institute of Virology, Vaccines and Sera, Torlak, Vojvode Stepe 458, 11000, Belgrade, Serbia., Minić R; Institute of Virology, Vaccines and Sera, Torlak, Vojvode Stepe 458, 11000, Belgrade, Serbia. Electronic address: rminic@torlak.rs.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2024 Aug; Vol. 190, pp. 114795. Date of Electronic Publication: 2024 Jun 06.
DOI: 10.1016/j.fct.2024.114795
Abstrakt: Porcine thyroglobulin was important in the discovery of alpha-Gal allergy. Here, the linkage of porcine thyroglobulin-specific IgE with IgE positivity to routinely assessed allergens and to the incoming diagnosis within a population of suspected atopic individuals is explored. IgE, IgA, total IgG and IgG subclasses to porcine thyroglobulin, IgE to bovine, human thyroglobulin and meat extract were measured with ELISA. The following correlations were observed in IgE binding to porcine and bovine thyroglobulin (r = 0.910, p = 1x10 -17 ), porcine and human thyroglobulin (r = 0.635, p = 4x10 -6 ), human and bovine thyroglobulin (r = 0.746, p = 6x10 -9 ) and porcine thyroglobulin and meat extract (r = 0.482, p = 0.0009). Only one out of ten samples which showed binding to porcine thyroglobulin in ELISA tested positive with ImmunoCAP alpha-Gal, implying different epitope/s. Increased IgE binding was detected towards a more electronegative fraction of porcine thyroglobulin separated according to charge and the binding could be partially inhibited by galactose. Anti-thyroglobulin IgE was found in 29.7% of the population, in subjects who were significantly younger, p < 0.0001 and it occurred more frequently in patients referred for testing penicillin specific IgE (OR 2.48, p = 0.0059) and were negative. IgE specific to porcine, bovine and possibly human thyroglobulin may be implicated in post-infectious skin manifestation misinterpreted as penicillin allergy.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: