Glyphosate and its formulated product Roundup Transorb R® affect locomotor activity and reproductive and developmental parameters in Jenynsia lineata fish: An intergenerational study.

Autor: Moraes JS; Programa de Pós-Graduação em Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Av. Itália km 8, 96203-900, Rio Grande, RS, Brazil. Electronic address: jenifersilveiramoraes@hotmail.com., Ballesteros ML; Instituto de Diversidad y Ecología Animal (IDEA), CONICET (Consejo Nacional de Investigaciones Científicas Y Técnicas), Córdoba, 5000, Argentina; Facultad de Ciencias Exactas, Físicas y Naturales, Cátedra de Diversidad Biológica IV, Universidad Nacional de Córdoba, Córdoba, 5000, Argentina. Electronic address: mlballesteros@unc.edu.ar., Hued AC; Instituto de Diversidad y Ecología Animal (IDEA), CONICET (Consejo Nacional de Investigaciones Científicas Y Técnicas), Córdoba, 5000, Argentina; Facultad de Ciencias Exactas, Físicas y Naturales, Cátedra de Diversidad Biológica IV, Universidad Nacional de Córdoba, Córdoba, 5000, Argentina. Electronic address: andrea.hued@unc.edu.ar., Bonifacio AF; Instituto de Diversidad y Ecología Animal (IDEA), CONICET (Consejo Nacional de Investigaciones Científicas Y Técnicas), Córdoba, 5000, Argentina; Facultad de Ciencias Exactas, Físicas y Naturales, Cátedra de Diversidad Biológica IV, Universidad Nacional de Córdoba, Córdoba, 5000, Argentina. Electronic address: alejo.bonifacio@unc.edu.ar., Azambuja TG; Instituto Federal de Educação, Ciência e Tecnologia Sul-rio-grandense, Campus Pelotas. Praça 20 de Setembro, 455, 96015360, Pelotas, RS, Brazil. Electronic address: thaiz.azambuja13@gmail.com., Vaz BDS; Instituto Federal de Educação, Ciência e Tecnologia Sul-rio-grandense, Campus Pelotas. Praça 20 de Setembro, 455, 96015360, Pelotas, RS, Brazil. Electronic address: bernardo.vaz@cnpq.br., Martins CMG; Programa de Pós-Graduação em Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande, Av. Itália km 8, 96203-900, Rio Grande, RS, Brazil. Electronic address: camilamartins@furg.br.
Jazyk: angličtina
Zdroj: Chemosphere [Chemosphere] 2024 Aug; Vol. 362, pp. 142541. Date of Electronic Publication: 2024 Jun 06.
DOI: 10.1016/j.chemosphere.2024.142541
Abstrakt: Glyphosate is the most widely utilized herbicide worldwide due to its effectiveness in controlling agricultural weeds. However, its persistence in aquatic ecosystems has raised concerns about the well-being of non-target organisms such as fish. This study aimed to evaluate the effects of chronic exposure (21 days) to glyphosate or its formulated product Roundup Transorb R®, at an environmentally relevant concentration permitted by regulations in certain countries (65 μg/L of glyphosate), on the locomotor activity and reproductive success of the fish Jenynsia lineata, as well as on the morphology/development and locomotor activity of its offspring, as intergenerational effects. Neither the pure nor formulated herbicide altered the distance traveled and velocity of adult fish exposed to the herbicide (F0), but they negatively affected reproductive success, decreasing the percentage of positive response to the presence of the female, reducing the number of gravid females, causing abortions, and lowering offspring survival (F1). In the F1 generation, a decrease in weight and length was noted along with developmental abnormalities in both treatment groups (pure or formulated glyphosate), with the formulation causing more harm. Observed developmental abnormalities included muscle atrophy, ascites, pigmentary disorders, vertebral agenesis, spinal deviation, and exophthalmia. Furthermore, parental exposure to pure glyphosate led to an increase in the distance traveled and velocity of F1 (hyperlocomotion), whereas exposure to the formulated product resulted in a decrease in these behaviors (hypolocomotion) of F1. These findings highlight the toxic effects of glyphosate at very low concentrations, although varying between pure and formulated, and demonstrate the intergenerational consequences of herbicide exposure, underscoring the risk to the survival of fish offspring in glyphosate-contaminated environments.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that may have influenced the work reported in this study.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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