Actigraphic monitoring of sleep and circadian rest-activity rhythm in individuals with major depressive disorder or depressive symptoms: A meta-analysis.

Autor: Ho FY; Department of Psychology, The Chinese University of Hong Kong, Hong Kong. Electronic address: fionahoyy@cuhk.edu.hk., Poon CY; Department of Psychology, The Chinese University of Hong Kong, Hong Kong., Wong VW; Department of Psychology, The Chinese University of Hong Kong, Hong Kong., Chan KW; Department of Psychology, The Chinese University of Hong Kong, Hong Kong., Law KW; Department of Psychology, The Chinese University of Hong Kong, Hong Kong., Yeung WF; School of Nursing, The Hong Kong Polytechnic University, Hong Kong., Chung KF; Department of Psychiatry, The University of Hong Kong, Hong Kong.
Jazyk: angličtina
Zdroj: Journal of affective disorders [J Affect Disord] 2024 Sep 15; Vol. 361, pp. 224-244. Date of Electronic Publication: 2024 Jun 06.
DOI: 10.1016/j.jad.2024.05.155
Abstrakt: Background: Disrupted sleep and rest-activity pattern are common clinical features in depressed individuals. This meta-analysis compared sleep and circadian rest-activity rhythms in people with major depressive disorder (MDD) or depressive symptoms and healthy controls.
Methods: Eligible studies were identified in five databases up to December 2023. The search yielded 53 studies with a total of 11,115 participants, including 4000 depressed participants and 7115 healthy controls.
Results: Pooled meta-analyses demonstrated that depressed individuals have significantly longer sleep latency (SMD = 0.23, 95 % CI: 0.12 to 0.33) and wake time after sleep onset (SMD = 0.37, 95 % CI: 0.22 to 0.52), lower sleep efficiency (SMD = -0.41, 95 % CI: -0.56 to -0.25), more nocturnal awakenings (SMD = 0.58, 95 % CI: 0.29 to 0.88), lower MESOR (SMD = -0.54, 95 % CI: -0.81 to -0.28), amplitude (SMD = -0.33, 95 % CI: -0.57 to -0.09), and interdaily stability (SMD = -0.17, 95 % CI: -0.28 to -0.05), less daytime (SMD = -0.79, 95 % CI: -1.08 to -0.49) and total activities (SMD = -0.89, 95 % CI: -1.28 to -0.50) when compared with healthy controls.
Limitations: Most of the included studies reported separate sleep and activity parameters instead of 24-hour rest-activity rhythms. The variabilities among actigraphy devices and the types of participants recruited also impede precise comparisons.
Conclusions: The findings emerging from this study offered a better understanding of sleep and rest-activity rhythm in individuals with MDD or depressive symptoms. Future studies could advocate for deriving objective, distinctive 24-hour rest-activity profiles contributing to the risk of depression.
Prospero Registration Number: CRD42021259780.
Competing Interests: Declaration of competing interest None.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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