Scoping Review of Factors Associated with Stem Cell Mobilization and Collection in Allogeneic Stem Cell Donors.

Autor: Peck RC; NHS Blood and Transplant, Bristol, United Kingdom; Faculty of Life Sciences, University of Bristol, Bristol, United Kingdom. Electronic address: rachel.peck@bristol.ac.uk., Knapp-Wilson A; Faculty of Life Sciences, University of Bristol, Bristol, United Kingdom., Burley K; Faculty of Life Sciences, University of Bristol, Bristol, United Kingdom., Dorée C; Systematic Review Initiative, NHS Blood and Transplant, Oxford, United Kingdom., Griffin J; NHS Blood and Transplant, Bristol, United Kingdom., Mumford AD; Faculty of Life Sciences, University of Bristol, Bristol, United Kingdom., Stanworth S; NHS Blood and Transplant, Bristol, United Kingdom; Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom., Sharplin K; NHS Blood and Transplant, Bristol, United Kingdom.
Jazyk: angličtina
Zdroj: Transplantation and cellular therapy [Transplant Cell Ther] 2024 Sep; Vol. 30 (9), pp. 844-863. Date of Electronic Publication: 2024 Jun 06.
DOI: 10.1016/j.jtct.2024.06.002
Abstrakt: There is wide interindividual variation in the efficacy of CD34 + cell mobilization and collection in healthy allogenic hematopoietic stem cell donors. Donor characteristics, blood cell counts, and various factors related to mobilization and collection have been associated with blood CD34 + cell count and CD34 + cell yield after granulocyte colony-stimulating factor (G-CSF) mobilization and collection. Given the heterogenous nature of the literature reporting these associations, in this scoping review we clarify the determinants of CD34 + count and yield. Studies published between 2000 and 2023 reporting allogeneic donors undergoing G-CSF mobilization and peripheral blood stem cell (PBSC) collection were evaluated. Eligible studies were those that assessed blood CD34 + cell count or CD34 + cell yield in the first PBSC collection after mobilization with 4 or 5 days of G-CSF treatment. Associations were recorded between these outcomes and donor factors (age, sex, weight, ethnicity), mobilization factors (G-CSF scheduling or dose), collection factors (venous access, processed blood volume [PBV]) or laboratory factors (blood cell counts at baseline or after mobilization). The 52 studies evaluated between 15 and 20,884 donors. Forty-three studies were retrospective, 33 assessed blood CD34 + cell counts, and 39 assessed CD34 + cell yield from PBSCs. Blood CD34 + cell counts consistently predicted CD34 + cell yield. Younger donors usually had higher blood CD34 + cell counts and CD34 + cell yield. Most studies that investigated the effect of donor ancestry found that donors of non-European ancestry had higher blood CD34 + cell counts after mobilization and higher CD34 + cell yields from collection. The poor consensus about the best predictors of blood CD34 + cell count and yield necessitates further prospective studies, particularly of the role of donor ancestry. The current focus on donor sex as a major predictor requires re-evaluation.
(Copyright © 2024 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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