An electrochemical sensing potential of cobalt oxide nanoparticles towards citric acid integrated with computational approach in food and biological media.

Autor: Ajab H; Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Pakistan. Electronic address: humaajab@cuiatd.edu.pk., Jafry AT; Faculty of Mechanical Engineering, GIK Institute of Engineering Sciences & Technology, Topi, District Swabi, KPK, 23640, Pakistan. Electronic address: ali.turab@giki.edu.pk., Sajid H; School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK. Electronic address: hasnain.sajid2019@myntu.ac.uk., Addicoat MA; School of Science and Technology, Nottingham Trent University, Nottingham NG11 8NS, UK. Electronic address: matthew.addicoat@ntu.ac.uk., Ayub K; Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Pakistan. Electronic address: khurshid@cuiatd.edu.pk., Haq MZU; Department of Chemistry, COMSATS University Islamabad, Abbottabad Campus, Pakistan.
Jazyk: angličtina
Zdroj: Food chemistry [Food Chem] 2024 Oct 15; Vol. 455, pp. 139869. Date of Electronic Publication: 2024 May 27.
DOI: 10.1016/j.foodchem.2024.139869
Abstrakt: Although citric acid (CA) has antioxidant, antibacterial, and acidulating properties, chronic ingestion of CA can cause urolithiasis, hypocalcemia, and duodenal cancer, emphasizing the need for early detection. There are very few documented electrochemical-based sensing methods for CA detection due to the challenging behavior of electrode fouling caused by reactive oxidation products. In this study, a novel, non-enzymatic, and economical electrochemical sensor based on cobalt oxide nanoparticles (CoO x NPs) is successfully reported for detection CA. The CoO x NPs were synthesized through a simple thermal decomposition method and characterized by SEM, FT-IR, EDX, and XRD techniques. The proposed sensing platform was optimized by various parameters, including pH (7.0), time (15 min), and concentration of nanoparticles (100 mM) etc. In a linear range of 0.05-2500 μM, a low detection limit (LOD) of 0.13 μM was achieved. Theoretical calculations (ΔRT), confirmed hydrogen bonding and electrostatic interactions between CoO x NPs and CA. The detection method exhibited high selectivity in real media like food and biological samples, with good recovery values when compared favorably to the HPLC method. To facilitate effective on-site investigation, such a sensing platform can be assembled into a portable device.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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