The guardian of intracranial vessels: Why the pericyte?

Autor: Cen K; Department of Neurology, Zhongnan Hospital Affiliated to Wuhan University, Wuhan 430000, China., Huang Y; Department of Neurology, Zhongnan Hospital Affiliated to Wuhan University, Wuhan 430000, China., Xie Y; Department of Neurology, Zhongnan Hospital Affiliated to Wuhan University, Wuhan 430000, China., Liu Y; Department of Neurology, Zhongnan Hospital Affiliated to Wuhan University, Wuhan 430000, China. Electronic address: Wb001792@whu.edu.cn.
Jazyk: angličtina
Zdroj: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 Jul; Vol. 176, pp. 116870. Date of Electronic Publication: 2024 Jun 07.
DOI: 10.1016/j.biopha.2024.116870
Abstrakt: Intracranial atherosclerotic stenosis (ICAS) is a pathological condition characterized by progressive narrowing or complete blockage of intracranial blood vessels caused by plaque formation. This condition leads to reduced blood flow to the brain, resulting in cerebral ischemia and hypoxia. Ischemic stroke (IS) resulting from ICAS poses a significant global public health challenge, especially among East Asian populations. However, the underlying causes of the notable variations in prevalence among diverse populations, as well as the most effective strategies for preventing and treating the rupture and blockage of intracranial plaques, remain incompletely comprehended. Rupture of plaques, bleeding, and thrombosis serve as precipitating factors in the pathogenesis of luminal obstruction in intracranial arteries. Pericytes play a crucial role in the structure and function of blood vessels and face significant challenges in regulating the Vasa Vasorum (VV)and preventing intraplaque hemorrhage (IPH). This review aims to explore innovative therapeutic strategies that target the pathophysiological mechanisms of vulnerable plaques by modulating pericyte biological function. It also discusses the potential applications of pericytes in central nervous system (CNS) diseases and their prospects as a therapeutic intervention in the field of biological tissue engineering regeneration.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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