Comparative effectiveness of preemptive administration of ibuprofen and ibuprofen-arginine on the anesthetic success of inferior alveolar nerve block in teeth with symptomatic irreversible pulpitis - A double-blind randomized clinical trial.

Autor: de Oliveira JP; Department of Stomatology, School of Dentistry, Federal University of Goiás, Setor Universitário, Goiânia, GO, 74605-220, Brazil., de Alencar AHG; Department of Stomatology, School of Dentistry, Federal University of Goiás, Setor Universitário, Goiânia, GO, 74605-220, Brazil., Estrela CB; Department of Endodontics, Paulista University, São Paulo, SP, Brazil., Decurcio DA; Department of Stomatology, School of Dentistry, Federal University of Goiás, Setor Universitário, Goiânia, GO, 74605-220, Brazil. danieldecurcio@ufg.br., Estrela CRA; Department Oral Biology, School of Dentistry and Medicine, Evangelical University of Goiás, Goiás, Brazil., Estrela C; Department of Stomatology, School of Dentistry, Federal University of Goiás, Setor Universitário, Goiânia, GO, 74605-220, Brazil.
Jazyk: angličtina
Zdroj: Clinical oral investigations [Clin Oral Investig] 2024 Jun 08; Vol. 28 (7), pp. 366. Date of Electronic Publication: 2024 Jun 08.
DOI: 10.1007/s00784-024-05765-5
Abstrakt: Objectives: This study examined the impact of premedication with ibuprofen and ibuprofen-arginine and the influence of preoperative pain and anxiety on inferior alveolar nerve block (IANB) efficacy in cases of symptomatic irreversible pulpitis.
Materials and Methods: The study involved 150 SIP patients who were randomly assigned to receive ibuprofen (600 mg), ibuprofen-arginine (1,155 mg), or a placebo 30 min before IANB. Preoperative anxiety and pain levels were assessed using the Modified Dental Anxiety Scale and the Heft-Parker visual scale. IANB efficacy was determined by the absence of or mild pain during the procedure. Statistical analysis included chi-square, z-tests, Analysis of Variance, and Student's t tests.
Results: The ibuprofen and ibuprofen-arginine groups exhibited significantly higher IANB success rates (62% and 78%, respectively) compared to the placebo group (34%). However, no significant difference was observed between the ibuprofen and ibuprofen-arginine groups. Patients with successful IANB in the ibuprofen and ibuprofen-arginine groups displayed lower median anxiety scores (8) than those with failed blocks (15) and lower mean preoperative pain scores (118.3).
Conclusion: In cases of symptomatic irreversible pulpitis the preemptive medication with ibuprofen-arginine effectively increased the efficacy of the inferior alveolar nerve block The inferior alveolar nerve block efficacy was influenced by preoperative anxiety levels and the intensity of pain.
Clinical Relevance: This research underscores the potential benefits of oral premedication with ibuprofen and ibuprofen-arginine in improving anesthesia outcomes in cases of symptomatic irreversible pulpitis.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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