The biodistribution of triamcinolone acetonide injections in severe keloids: an exploratory three-dimensional fluorescent cryomicrotome study.

Autor: Yin Q; Department of Dermatology, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands., Bekkers VZ; Department of Dermatology, Erasmus Medical Center, Dr. Molewaterplein 40, Rotterdam, The Netherlands., Roelofs MCM; Department of Dermatology, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands., Dobbe JGG; Biomedical Engineering and Physics, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands., de Vos J; Biomedical Engineering and Physics, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands., Bloemen PR; Biomedical Engineering and Physics, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands., Aalders MCG; Biomedical Engineering and Physics, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands., Gibbs S; Department of Molecular Cell Biology & Immunology, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands., Lapid O; Amsterdam Movement Sciences, Amsterdam University Medical Center, Amsterdam, the Netherlands.; Department of Plastic, Reconstructive and Hand Surgery, Amsterdam UMC location Vrije Universiteit, De Boelelaan 1117, Amsterdam, The Netherlands., Niessen FB; Department of Plastic, Reconstructive and Hand Surgery, Amsterdam UMC location Vrije Universiteit, De Boelelaan 1117, Amsterdam, The Netherlands., van Doorn MBA; Department of Dermatology, Erasmus Medical Center, Dr. Molewaterplein 40, Rotterdam, The Netherlands., Wolkerstorfer A; Department of Dermatology, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands. a.wolkerstorfer@amsterdamumc.nl.
Jazyk: angličtina
Zdroj: Archives of dermatological research [Arch Dermatol Res] 2024 Jun 08; Vol. 316 (7), pp. 368. Date of Electronic Publication: 2024 Jun 08.
DOI: 10.1007/s00403-024-03041-w
Abstrakt: Intralesional corticosteroid injections are a first-line treatment for keloids; yet clinical treatment results are highly variable and often suboptimal. Variation in triamcinolone acetonide (TAC) biodistribution may be an important reason for the variable effects of TAC treatment in keloids. In this exploratory study we investigated the biodistribution of TAC in keloids and normal skin using different drug delivery techniques. Fluorescent-labeled TAC suspension was administered into keloids and normal skin with a hypodermic needle and an electronic pneumatic jet injector. TAC biodistribution was represented by the fluorescent TAC volume and 3D biodistribution shape of TAC, using a 3D-Fluorescence-Imaging Cryomicrotome System. Twenty-one keloid and nine normal skin samples were analyzed. With needle injections, the mean fluorescent TAC volumes were 990 µl ± 479 in keloids and 872 µl ± 227 in normal skin. With the jet injector, the mean fluorescent TAC volumes were 401 µl ± 252 in keloids and 249 µl ± 67 in normal skin. 3D biodistribution shapes of TAC were highly variable in keloids and normal skin. In conclusion, TAC biodistribution in keloids is highly variable for both needle and jet injection. This may partly explain the variable treatment effects of intralesional TAC in keloids. Future research is needed to confirm this preliminary finding and to optimize drug delivery in keloids.
(© 2024. The Author(s).)
Databáze: MEDLINE
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