Current status of mannose receptor-targeted drug delivery for improved anti-HIV therapy.

Autor: Rojekar S; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: rojekarsatish@gmail.com., Gholap AD; Department of Pharmaceutics, St. John Institute of Pharmacy and Research, Palghar 401404, Maharashtra, India., Togre N; Department of Pathology, Lewis Katz School of Medicine at Temple University, Philadelphia, USA., Bhoj P; Department of Pathology, Lewis Katz School of Medicine at Temple University, Philadelphia, USA., Haeck C; Population Council, , Center for Biomedical Research, 1230 York Avenue, New York, NY 10065, USA., Hatvate N; Institute of Chemical Technology, Mumbai, Marathwada Campus, Jalna 431203, India., Singh N; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Kolkata 700054, India., Vitore J; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), Gujarat 382355, India., Dhoble S; Department of Pharmacology and Toxicology, R. K. Coit College of Pharmacy, University of Arizona, Tucson, AZ, USA., Kashid S; Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), Gujarat 382355, India., Patravale V; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai 400019, India. Electronic address: vb.patravale@ictmumbai.edu.in.
Jazyk: angličtina
Zdroj: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2024 Aug; Vol. 372, pp. 494-521. Date of Electronic Publication: 2024 Jun 27.
DOI: 10.1016/j.jconrel.2024.06.002
Abstrakt: In the pursuit of achieving better therapeutic outcomes in the treatment of HIV, innovative drug delivery strategies have been extensively explored. Mannose receptors, which are primarily found on macrophages and dendritic cells, offer promising targets for drug delivery due to their involvement in HIV pathogenesis. This review article comprehensively evaluates recent drug delivery system advancements targeting the mannose receptor. We have systematically described recent developments in creating and utilizing drug delivery platforms, including nanoparticles, liposomes, micelles, noisomes, dendrimers, and other nanocarrier systems targeted at the mannose receptor. These strategies aim to enhance drug delivery specificity, bioavailability, and therapeutic efficacy while decreasing off-target effects and systemic toxicity. Furthermore, the article delves into how mannose receptors and HIV interact, highlighting the potential for exploiting this interaction to enhance drug delivery to infected cells. The review covers essential topics, such as the rational design of nanocarriers for mannose receptor recognition, the impact of physicochemical properties on drug delivery performance, and how targeted delivery affects the pharmacokinetics and pharmacodynamics of anti-HIV agents. The challenges of these novel strategies, including immunogenicity, stability, and scalability, and future research directions in this rapidly growing area are discussed. The knowledge synthesis presented in this review underscores the potential of mannose receptor-based targeted drug delivery as a promising avenue for advancing HIV treatment. By leveraging the unique properties of mannose receptors, researchers can design drug delivery systems that cater to individual needs, overcome existing limitations, and create more effective and patient-friendly treatments in the ongoing fight against HIV/AIDS.
Competing Interests: Declaration of competing interest All authors declare no conflict of interest.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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