The influence of wakefulness fluctuations on brain networks involved in centrotemporal spike occurrence.

Autor: Talami F; Institute of Neuroscience, National Research Council of Italy, Parma, Italy; Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy., Lemieux L; Department of Clinical and Experimental and Experimental Epilepsy, UCL Queen Square Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom., Avanzini P; Institute of Neuroscience, National Research Council of Italy, Parma, Italy., Ballerini A; Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy., Cantalupo G; Innovation Biomedicine Section, Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy; Child Neuropsychiatry Unit and Center for Research on Epilepsies in Pediatric age (CREP), University Hospital of Verona (full member of the European Reference Network EpiCARE), Verona, Italy., Laufs H; University Medical Center Schleswig-Holstein, Christian-Albrechts-Universität zu Kiel, Germany., Meletti S; Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Neurophysiology Unit and Epilepsy Centre, Neuroscience Department, AOU Modena, Italy. Electronic address: stefano.meletti@unimore.it., Vaudano AE; Department of Biomedical, Metabolic, and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy; Neurophysiology Unit and Epilepsy Centre, Neuroscience Department, AOU Modena, Italy. Electronic address: annaelisabetta.vaudano@unimore.it.
Jazyk: angličtina
Zdroj: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology [Clin Neurophysiol] 2024 Aug; Vol. 164, pp. 47-56. Date of Electronic Publication: 2024 May 24.
DOI: 10.1016/j.clinph.2024.05.005
Abstrakt: Objective: Drowsiness has been implicated in the modulation of centro-temporal spikes (CTS) in Self-limited epilepsy with Centro-Temporal Spikes (SeLECTS). Here, we explore this relationship and whether fluctuations in wakefulness influence the brain networks involved in CTS generation.
Methods: Functional MRI (fMRI) and electroencephalography (EEG) was simultaneously acquired in 25 SeLECTS. A multispectral EEG index quantified drowsiness ('EWI': EEG Wakefulness Index). EEG (Pearson Correlation, Cross Correlation, Trend Estimation, Granger Causality) and fMRI (PPI: psychophysiological interactions) analytic approaches were adopted to explore respectively: (a) the relationship between EWI and changes in CTS frequency and (b) the functional connectivity of the networks involved in CTS generation and wakefulness oscillations. EEG analyses were repeated on a sample of routine EEG from the same patient's cohort.
Results: No correlation was found between EWI fluctuations and CTS density during the EEG-fMRI recordings, while they showed an anticorrelated trend when drowsiness was followed by proper sleep in routine EEG traces. According to PPI findings, EWI fluctuations modulate the connectivity between the brain networks engaged by CTS and the left frontal operculum.
Conclusions: While CTS frequency per se seems unrelated to drowsiness, wakefulness oscillations modulate the connectivity between CTS generators and key regions of the language circuitry, a cognitive function often impaired in SeLECTS.
Significance: This work advances our understanding of (a) interaction between CTS occurrence and vigilance fluctuations and (b) possible mechanisms responsible for language disruption in SeLECTS.
(Copyright © 2024 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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