Subcision with and without suction for acne scars: a split-faced, rater-blinded randomized control trial.

Autor: Shi VJ; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Ma MS; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Koza E; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Haq M; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Ahmed A; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Yi MD; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Dirr MA; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Anvery N; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Christensen RE; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Pagdhal K; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Geisler A; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Nodzenski M; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Roongpisuthipong W; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Division of Dermatology, Department of Medicine, Vajira Hospital, Navamindrahiraj University, Bangkok, 10300, Thailand., Brieva JC; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Cahn BA; Division of Dermatology, University of Illinois-Chicago College of Medicine, Chicago, IL, USA., Yoo SS; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Lucas J; Department of Dermatology, Cleveland Clinic, Cleveland, OH, USA., Poon E; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., West DP; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Fife D; Vivida Dermatology, Las Vegas, NV, USA., Alam M; Department of Dermatology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. m-alam@northwestern.edu.; Department of Otolaryngology- Head and Neck Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. m-alam@northwestern.edu.; Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. m-alam@northwestern.edu.
Jazyk: angličtina
Zdroj: Archives of dermatological research [Arch Dermatol Res] 2024 Jun 07; Vol. 316 (7), pp. 344. Date of Electronic Publication: 2024 Jun 07.
DOI: 10.1007/s00403-024-03128-4
Abstrakt: Therapeutic options for acne scars include subcision and suction with microdermabrasion, but these treatment modalities have not been studied in conjunction. To compare effectiveness of subcision alone versus subcision with suction for the treatment of facial acne scars. Randomized, split-faced, evaluator-blinded control trial. Participants underwent one subcision treatment on both sides of the face followed by 10 sessions of suction to one side. Photographs at baseline, 1-month, and 4-months were assessed. Primary outcome measures were the validated Acne Scar Severity Scale (ASSS) (0 = no acne scarring, 4 = severe), Acne Scar Improvement Grading Scale (ASIGS) (-100 to 100%), and modified Quantitative Global Scarring Grades (QGSG) (point-based questionnaire instrument), as well as subject preference. Twenty-eight treatment areas and 154 treatments were analyzed. Dermatologist raters found no differences between subcision alone and subcision-suction at 1-month or 4-months. Mean subject-assessed percent improvement for subcision-suction was higher than that for subcision alone at 1-month (37% versus 24%, p = 0.04) but not at 4-months (p = 0.37). Subjects preferred combination therapy to monotherapy at 1-month (50% vs. 21%) and 4-months (43% vs. 21%). While blinded raters did not detect significant differences, subjects perceived combination treatment as working more quickly than monotherapy, and preferred combination treatment at all time points.Clinical trial registration NCT01696513 on Clinicaltrials.gov.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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