Multifunctional Dopamine-Based Hydrogel Microneedle Electrode for Continuous Ketone Sensing.

Autor: Ausri IR; Department of Electrical and Computer Engineering, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.; Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON, N2L 3G1, Canada., Sadeghzadeh S; Department of Electrical and Computer Engineering, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.; Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON, N2L 3G1, Canada., Biswas S; Department of Electrical and Computer Engineering, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.; Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON, N2L 3G1, Canada., Zheng H; Department of Electrical and Computer Engineering, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.; Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON, N2L 3G1, Canada., GhavamiNejad P; Department of Electrical and Computer Engineering, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.; Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON, N2L 3G1, Canada., Huynh MDT; Department of Electrical and Computer Engineering, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.; Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON, N2L 3G1, Canada., Keyvani F; Department of Electrical and Computer Engineering, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.; Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON, N2L 3G1, Canada., Shirzadi E; Department of Electrical and Computer Engineering, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.; Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON, N2L 3G1, Canada., Rahman FA; Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, N2L 3G1, Canada., Quadrilatero J; Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, N2L 3G1, Canada., GhavamiNejad A; Advanced Pharmaceutics and Drug Delivery Laboratory, Leslie L. Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, M5S 3M2, Canada., Poudineh M; Department of Electrical and Computer Engineering, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.; Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON, N2L 3G1, Canada.
Jazyk: angličtina
Zdroj: Advanced materials (Deerfield Beach, Fla.) [Adv Mater] 2024 Aug; Vol. 36 (32), pp. e2402009. Date of Electronic Publication: 2024 Jun 16.
DOI: 10.1002/adma.202402009
Abstrakt: Diabetic ketoacidosis (DKA), a severe complication of type 1 diabetes (T1D), is triggered by production of large quantities of ketone bodies, requiring patients with T1D to constantly monitor their ketone levels. Here, a skin-compatible hydrogel microneedle (HMN)-continuous ketone monitoring (HMN-CKM) device is reported. The sensing mechanism relies on the catechol-quinone chemistry inherent to the dopamine (DA) molecules that are covalently linked to the polymer structure of the HMN patch. The DA serves the dual-purpose of acting as a redox mediator for measuring the byproduct of oxidation of 3-beta-hydroxybutyrate (β-HB), the primary ketone bodies; while, also facilitating the formation of a crosslinked HMN patch. A universal approach involving pre-oxidation and detection of the generated catechol compounds is introduced to correlate the sensor response to the β-HB concentrations. It is further shown that real-time tracking of a decrease in ketone levels of T1D rat model is possible using the HMN-CKM device, in conjunction with a data-driven machine learning model that considers potential time delays.
(© 2024 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
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