School holidays and respiratory syncytial virus transmission in Sweden: An interrupted time series analysis.

Autor: Dallagiacoma G; Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.; Department of Public Health, Experimental and Forensic Medicine, School of Public Health, University of Pavia, Pavia, Italy., Radó MK; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Odone A; Department of Public Health, Experimental and Forensic Medicine, School of Public Health, University of Pavia, Pavia, Italy., Alfvén T; Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.; Sachs' Children and Youth Hospital, Stockholm, Sweden., Rhedin SA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; Sachs' Children and Youth Hospital, Stockholm, Sweden.
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2024 Sep; Vol. 113 (9), pp. 2081-2090. Date of Electronic Publication: 2024 Jun 07.
DOI: 10.1111/apa.17313
Abstrakt: Aim: Respiratory syncytial virus (RSV) represents a significant cause of morbidity for children worldwide, especially for newborns. As RSV vaccines are not routinely used for children yet, non-pharmaceutical interventions (NPIs) represent the main strategy for prevention. The objective of this study was to investigate the correlation between school holidays and RSV transmission.
Methods: Data were collected from the weekly reports on RSV incidence for the 2021/2022 and 2022/2023 seasons in Sweden. The 7-day cumulative incidence of RSV was compared before and after the designated school holidays (Fall, Christmas, and Winter holidays).
Results: Our findings reveal an immediate (-1.7%, p < 0.001, 95% CI [-3.1%, -0.4%]) and gradual (-1.4%/week, p < 0.001, 95%CI [-1.8, -1.0]) reduction in RSV incidence following the Fall holiday in 2021, especially among children under 1 year of age, both immediately (-107.6%, p < 0.05, 95% CI [-203.7, -11.5]) and gradually afterwards (-58.5%/week, p < 0.001, 95% CI [-72.7, -44.3]). Mixed results were obtained for the Fall in 2022/2023 and for the Winter and holidays in both the studied years.
Conclusions: While the Fall holiday in 2021/2022 was associated with a decrease in RSV incidence in Sweden, our results do not support a universal effect of school holidays on reducing RSV transmission.
(© 2024 The Author(s). Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.)
Databáze: MEDLINE
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