Association of cord blood vitamin D with child neurodevelopment at 7 years of age.

Autor: Gould JF; Discipline of Public Health, SAHMRI Women and Kids, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.; Discipline of Public Health, School of Psychology, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.; Discipline of Public Health, Discipline of Paediatrics, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia., Cuthbert AR; Discipline of Public Health, SAHMRI Women and Kids, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia., Yelland LN; Discipline of Public Health, SAHMRI Women and Kids, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.; Discipline of Public Health, School of Public Health, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia., Gibson RA; Discipline of Public Health, SAHMRI Women and Kids, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.; Discipline of Public Health, Discipline of Paediatrics, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.; Discipline of Public Health, School of Agriculture, Food & Wine, University of Adelaide, Adelaide, South Australia, Australia., Smithers LG; Discipline of Public Health, Faculty of the Arts, Social Sciences and Humanities, School of Health and Society, University of Wollongong, Wollongong, New South Wales, Australia., Zhou SJ; Discipline of Public Health, School of Agriculture, Food & Wine, University of Adelaide, Adelaide, South Australia, Australia., Makrides M; Discipline of Public Health, SAHMRI Women and Kids, South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.; Discipline of Public Health, Discipline of Paediatrics, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, South Australia, Australia.
Jazyk: angličtina
Zdroj: Journal of paediatrics and child health [J Paediatr Child Health] 2024 Jul; Vol. 60 (7), pp. 312-322. Date of Electronic Publication: 2024 Jun 07.
DOI: 10.1111/jpc.16590
Abstrakt: Aim: The role of fetal vitamin D [25-hydroxyvitamin D (25(OH)D)], one of the nuclear steroid transcription regulators, and brain development is unclear. We previously found a weak but persistent association between cord blood 25(OH)D and child language abilities at 18 months and 4 years of age, but no association with cognition or behaviour. The aim of this study was to investigate the association between cord blood 25(OH)D and a range of neurodevelopmental outcomes in these same children at 7 years of age.
Methods: Cord blood samples from 250 Australian mother-child pairs were analysed for 25(OH)D by mass spectroscopy. Children underwent tests of cognition, language, academic abilities and executive functions with a trained assessor at 7 years of age. Caregivers completed questionnaires to rate their child's behaviour and executive functioning in the home environment. Associations between standardised 25(OH)D and outcomes were assessed using regression models, taking into account possible social and demographic confounders.
Results: Standardised 25(OH)D in cord blood was not associated with any test or parent-rated scores. Nor was there any association with the risk of having a poor test or parent-rated score. Likewise, cord blood 25(OH)D categorised as <25, 25-50 and >50 nmol/L was not associated with test scores or parent-rated scores.
Conclusions: There was no evidence that cord blood vitamin D concentration or deficiency was associated with cognition, language, academic abilities, executive functioning or behaviour at 7 years of age.
(© 2024 The Author(s). Journal of Paediatrics and Child Health published by John Wiley & Sons Australia, Ltd on behalf of Paediatrics and Child Health Division (The Royal Australasian College of Physicians).)
Databáze: MEDLINE
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