Sarcopenia Identification Using Alternative Vertebral Landmarks in Individuals with Lung Cancer.

Autor: Byrne CA; Cancer Health Equity and Career Development Program, University of Illinois Chicago, 1747 W. Roosevelt Rd., Chicago, IL 60608, USA., Fantuzzi G; Department of Kinesiology and Nutrition, University of Illinois Chicago, 1919 W. Taylor St., Chicago, IL 60612, USA., Stephan JT; Department of Radiology, Rush University Medical Center, 1653 W. Congress Parkway, Chicago, IL 60612, USA., Kim S; School of Public Health, University of Illinois Chicago, 1603 W. Taylor St., Chicago, IL 60612, USA., Oddo VM; Department of Kinesiology and Nutrition, University of Illinois Chicago, 1919 W. Taylor St., Chicago, IL 60612, USA., Koh TJ; Department of Kinesiology and Nutrition, University of Illinois Chicago, 1919 W. Taylor St., Chicago, IL 60612, USA., Gomez SL; Department of Clinical Nutrition, Rush University, 600 S. Paulina St., Chicago, IL 60612, USA.
Jazyk: angličtina
Zdroj: Muscles (Basel, Switzerland) [Muscles] 2024 Jun; Vol. 3 (2), pp. 121-132. Date of Electronic Publication: 2024 Apr 16.
DOI: 10.3390/muscles3020012
Abstrakt: Background: (1)Sarcopenia, or low skeletal mass index (SMI), contributes to higher lung cancer mortality. The SMI at third lumbar vertebrae (L3) is the reference standard for body composition analysis. However, there is a need to explore the validity of alternative landmarks in this population. We compared the agreement of sarcopenia identification at the first lumbar (L1) and second lumbar (L2) to L3 in non-Hispanic Black (NHB) and White (NHW) individuals with lung cancer.
Methods: (2)This retrospective, cross-sectional study included 214 NHB and NHW adults with lung cancer. CT scans were analyzed to calculate the SMI at L1, L2, and L3. T-tests, chi-square, Pearson's correlation, Cohen's kappa, sensitivity, and specificity analysis were used.
Results: (3)Subjects presented with a mean age of 68.4 ± 9.9 years and BMI of 26.3 ± 6.0 kg/m 2 . Sarcopenia prevalence varied from 19.6% at L1 to 39.7% at L3. Cohen's kappa coefficient was 0.46 for L1 and 0.64 for L2, indicating weak and moderate agreement for the identification of sarcopenia compared to L3.
Conclusions: (4)Sarcopenia prevalence varied greatly depending on the vertebral landmark used for assessment. Using L2 or L1 alone resulted in a 16.8% and 23.8% misclassification of sarcopenia in this cohort of individuals with lung cancer.
Competing Interests: Conflicts of Interest: The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje