Tailoring epilepsy treatment: personalized micro-physiological systems illuminate individual drug responses.

Autor:	Shariff S; Oli Health Magazine Organization, Research and Education, Kigali, Rwanda.; Yerevan State Medical University, Yerevan, Armenia., Kantawala B; Oli Health Magazine Organization, Research and Education, Kigali, Rwanda.; Yerevan State Medical University, Yerevan, Armenia., Xochitun Gopar Franco W; Oli Health Magazine Organization, Research and Education, Kigali, Rwanda.; University of Guadalajara, Guadalajara, Mexico., Dejene Ayele N; Oli Health Magazine Organization, Research and Education, Kigali, Rwanda.; Department of Internal Medicine, Faculty of Medicine, Wolkite University, Wolkite, Ethiopia., Munyangaju I; Oli Health Magazine Organization, Research and Education, Kigali, Rwanda.; College of Medicine and General Surgery, Sudan University Of Science and Technology, Khartoum, Sudan., Esam Alzain F; Oli Health Magazine Organization, Research and Education, Kigali, Rwanda.; College of Medicine and General Surgery, Sudan University Of Science and Technology, Khartoum, Sudan., Nazir A; Oli Health Magazine Organization, Research and Education, Kigali, Rwanda.; Department of Medicine, King Edward Medical University, Lahore, Pakistan., Wojtara M; Oli Health Magazine Organization, Research and Education, Kigali, Rwanda., Uwishema O; Oli Health Magazine Organization, Research and Education, Kigali, Rwanda.; Clinton Global Initiative University, New York, NY.; Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Jazyk:	angličtina
Zdroj:	Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2024 Apr 16; Vol. 86 (6), pp. 3557-3567. Date of Electronic Publication: 2024 Apr 16 (Print Publication: 2024).
DOI:	10.1097/MS9.0000000000002078
Abstrakt:	Introduction: Approximately 50 million people worldwide have epilepsy, with many not achieving seizure freedom. Organ-on-chip technology, which mimics organ-level physiology, could revolutionize drug development for epilepsy by replacing animal models in preclinical studies. The authors' goal is to determine if customized micro-physiological systems can lead to tailored drug treatments for epileptic patients. Materials and Methods: A comprehensive literature search was conducted utilizing various databases, including PubMed, Ebscohost, Medline, and the National Library of Medicine, using a predetermined search strategy. The authors focused on articles that addressed the role of personalized micro-physiological systems in individual drug responses and articles that discussed different types of epilepsy, diagnosis, and current treatment options. Additionally, articles that explored the components and design considerations of micro-physiological systems were reviewed to identify challenges and opportunities in drug development for challenging epilepsy cases. Results: The micro-physiological system offers a more accurate and cost-effective alternative to traditional models for assessing drug effects, toxicities, and disease mechanisms. Nevertheless, designing patient-specific models presents critical considerations, including the integration of analytical biosensors and patient-derived cells, while addressing regulatory, material, and biological complexities. Material selection, standardization, integration of vascular systems, cost efficiency, real-time monitoring, and ethical considerations are also crucial to the successful use of this technology in drug development. Conclusion: The future of organ-on-chip technology holds great promise, with the potential to integrate artificial intelligence and machine learning for personalized treatment of epileptic patients. Competing Interests: The authors declare that they have no conflicts of interest.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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