The Relationship between Leptin Levels and Continuous Positive Airway Pressure Treatment: A Cluster Analysis.

Autor:	Oki T; Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan., Kozu Y; Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan., Hoshi M; Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan., Itoda Y; Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan., Furusho N; Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan., Ozoe R; Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan., Jinno Y; Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan., Hirata A; Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan., Kurosawa Y; Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan., Yamada S; Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan., Fukuda A; Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan., Hikichi M; Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan., Shikano S; Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan., Sugaya K; Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan., Hiranuma H; Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan., Maruoka S; Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan., Gon Y; Department of Internal Medicine, Division of Respiratory Medicine, School of Medicine, Nihon University, Itabashiku, Tokyo, Japan.
Jazyk:	angličtina
Zdroj:	Sleep science (Sao Paulo, Brazil) [Sleep Sci] 2024 Feb 27; Vol. 17 (2), pp. e143-e150. Date of Electronic Publication: 2024 Feb 27 (Print Publication: 2024).
DOI:	10.1055/s-0043-1777779
Abstrakt:	Objective  Leptin is an appetite-suppressing hormone released by adipose tissue that plays an important role in severe obstructive sleep apnea syndrome (OSAS). However, it is unclear whether leptin levels are a useful biomarker for this syndrome. The present study aimed to assess the effect of continuous positive airway pressure (CPAP) treatment on the syndrome according to leptin levels, using a cluster classification based on clinical features of the syndrome. Materials and Methods  We performed a hierarchical cluster analysis of data from 97 OSAS patients diagnosed via polysomnography. We also evaluated the effect after 6 months of CPAP administration. Results  Clusters 1 (49 patients; 50.5%) and 2 (6 patients; 6.2%) presented normal leptin levels, and clusters 3 (11 patients; 11.3%) and 4 (31 patients; 32%) presented high leptin levels. Clusters 3 and 4 presented different leptin levels, but the same degree of obesity. After treatment, the levels of excessive daytime sleepiness improved in all clusters. In Cluster 3, leptin levels were significantly reduced after treatment. Conclusion  Using the conventional diagnostic method of the apnea-hypopnea index, it was not clear whether leptin is a useful biomarker for the CPAP treatment. However, it may be helpful for particular clusters, including obese women, and where particular populations require CPAP treatment. Competing Interests: Conflict of Interests The authors have no conflict of interests to declare. (Brazilian Sleep Association. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu