Effect of the vaccination against Shiga toxin 2e in a farm with history of oedema disease, caused by atypical Escherichia coli producing Shiga toxin (STEC).

Autor: Sperling D; Ceva Sante Animale France, Libourne, France., Isaka N; Ceva Sante Animale France, Libourne, France., Karembe H; Ceva Sante Animale France, Libourne, France., Vanhara J; Ceva Sante Animale France, Libourne, France.; Swine and Ruminant Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences Brno, Brno, Czech Republic., Vinduska J; ZOD Zichlinek, Zichlinek, Czech Republic., Strakova N; Veterinary Research Institute, Brno, Czech Republic., Kalova A; Veterinary Research Institute, Brno, Czech Republic.; Department of Experimental Biology, Faculty of Science, Masaryk University Brno, Brno, Czech Republic., Kolackova I; Veterinary Research Institute, Brno, Czech Republic., Karpiskova R; Veterinary Research Institute, Brno, Czech Republic.
Jazyk: angličtina
Zdroj: Veterinarni medicina [Vet Med (Praha)] 2022 Sep 01; Vol. 67 (10), pp. 510-518. Date of Electronic Publication: 2022 Sep 01 (Print Publication: 2022).
DOI: 10.17221/36/2022-VETMED
Abstrakt: Oedema disease of weaned piglets is caused by shigatoxigenic Escherichia coli (STEC), typically harbouring the stx2e gene and F18 adhesins. The aim of this study was to assess the effect of a commercially available oedema disease vaccine on the zootechnical performance, mortality and individual antibiotic treatment in a herd, in which non-typical STEC strains without F18 adhesin have been identified. The zootechnical performance (average daily gain, total weight gain), mortality and individual antibiotic treatment were compared between vaccinated and non-vaccinated control piglets in a monocentric field efficacy study, which was performed using two groups in a parallel, randomised design. A significantly higher average daily gain and total weight gain were recorded in the vaccinated piglets in comparison to the controls. The lower morbidity, mortality and antibiotic treatment in piglets in the vaccine group were not statistically significant. As a conclusion, the positive effect of the vaccination was confirmed in the herd with prevalent STEC not harbouring F18 adhesin. The vaccine was, therefore, also effective against oedema disease caused by such unusual STEC isolates, under the conditions of this study.
Competing Interests: The authors DS, HK and JV declare that they are employees of the company Ceva Sante Animale France, which currently markets the vaccine ECOPORC SHIGA. The authors JV, NS, AK, IK, RK declare no conflict of interest. The funders had no role analyses or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
(Copyright: © 2022 Sperling et al.)
Databáze: MEDLINE
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