Decellularized tissues as platforms for digestive system cancer models.

Autor:	Seifi Z; Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran., Khazaei M; Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.; Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran., Cheraghali D; Department of Mechanical Engineering, New Jersey Institute of Technology, NJ, USA., Rezakhani L; Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.; Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2024 May 21; Vol. 10 (11), pp. e31589. Date of Electronic Publication: 2024 May 21 (Print Publication: 2024).
DOI:	10.1016/j.heliyon.2024.e31589
Abstrakt:	The extracellular matrix (ECM) is a multifunctional network of macromolecules that regulate various cellular functions and physically support the tissues. Besides physiological conditions, the ECM also changes during pathological conditions such as cancer. As tumor cells proliferate, notable changes occur in the quantity and makeup of the surrounding ECM. Therefore, the role of this noncellular component of tissues in studies of tumor microenvironments should be considered. So far, many attempts have been made to create 2-dimensional (2D) or 3-dimensional (3D) models that can replicate the intricate connections within the tumor microenvironment. Decellularized tissues are proper scaffolds that imitate the complex nature of native ECM. This review aims to summarize 3D models of digestive system cancers based on decellularized ECMs. These ECM-based scaffolds will enable us to study the interactive communication between cells and their surrounding environment which brings new potential for a better understanding of the pathophysiology of cancer. Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dr. Leila Rezakhani reports was provided by Department of Tissue Engineering, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Authors.)
Databáze:	MEDLINE
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