Disparities and barriers to the access of biologics in moderate-to-severe adult psoriasis.

Autor: Wan V; Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Habibi A; Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada., Mija LA; Faculté de Médecine, Université de Montréal, Montréal, QC, Canada., Abdi P; Memorial University of Newfoundland Faculty of Medicine, St. Johns, NL, Canada., Selvakumar R; University of British Columbia, Vancouver, BC, Canada., Mukovozov I; Toronto Dermatology Centre, Toronto, ON, Canada.
Jazyk: angličtina
Zdroj: International journal of dermatology [Int J Dermatol] 2024 Oct; Vol. 63 (10), pp. 1293-1301. Date of Electronic Publication: 2024 Jun 06.
DOI: 10.1111/ijd.17236
Abstrakt: Psoriasis is a chronic, relapsing inflammatory skin disorder that is associated with substantial physical and psychosocial comorbidity. Although biologic agents have offered transformative therapeutic advantages to those unresponsive to traditional treatments, data from recent literature indicate significant undertreatment of certain populations, highlighting potential barriers to access. This review aims to comprehensively elucidate barriers to biological therapy, addressing a recognized gap in the current literature. A search was conducted using MEDLINE, Embase, and Web of Science to investigate the obstacles and disparities that prevent access to biologic treatments in biologic-naïve psoriatic patients. Emergent themes were then systematically categorized into five primary domains: patient-level, prescriber-level, medicine-level, organizational-, and external environment-level factors. Our results demonstrate pronounced barriers and disparities encompassing increased age, race, socioeconomic status, rural location, cost and insurance, and insufficient knowledge that may hinder access to biologic treatments among psoriatic patients. Further research on how these barriers can be effectively addressed is needed to optimize treatment outcomes.
(© 2024 The Authors. International Journal of Dermatology published by Wiley Periodicals LLC on behalf of the International Society of Dermatology.)
Databáze: MEDLINE
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