Echocardiographic surrogate of left ventricular stroke work in a model of brain stem death donors.

Autor: Sato K; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Hoe LS; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.; School of Pharmacy and Medical Sciences, Griffith University, Southport, Queensland, Australia., Chan J; Division of Cardiology, The Prince Charles Hospital, Brisbane, Queensland, Australia.; School of Medicine, Griffith University, Gold Coast, Queensland, Australia., Obonyo NG; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.; Wellcome Trust Centre for Global Health Research, Imperial College London, London, UK.; Initiative to Develop African Research Leaders (IDeAL)/KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Wildi K; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.; Cardiovascular Research Institute Basel, Basel, Switzerland., Heinsar S; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.; Department of Intensive Care, North Estonia Medical Centre, Tallinn, Estonia., Colombo SM; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.; Department of Anesthesia, Critical Care and Emergency, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy., Ainola C; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Abbate G; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Sato N; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Passmore MR; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Bouquet M; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Wilson ES; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Hyslop K; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Livingstone S; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Haymet A; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Jung JS; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.; Department of Thoracic and Cardiovascular Surgery, College of Medicine, Korea University, Seoul, Republic of Korea., Skeggs K; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Princess Alexandra Hospital, Brisbane, Queensland, Australia., Palmieri C; Faculty of Science, School of Veterinary Science, University of Queensland, Gatton, Queensland, Australia., White N; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Faculty of Health, School of Public Health and Social Work, Queensland University of Technology, Brisbane, Queensland, Australia., Platts D; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia., Suen JY; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.; School of Pharmacy and Medical Sciences, Griffith University, Southport, Queensland, Australia., McGiffin DC; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Cardiothoracic Surgery and Transplantation, The Alfred Hospital, Melbourne, Victoria, Australia.; The Department of Surgery, Monash University, Melbourne, Victoria, Australia., Bassi GL; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.; Intensive Care Units, St Andrew's War Memorial Hospital, The Wesley Hospital, Uniting Care Hospitals, Brisbane, Queensland, Australia.; Medical Faculty, Queensland University of Technology, Brisbane, Queensland, Australia., Fraser JF; Critical Care Research Group, The Prince Charles Hospital, Brisbane, Queensland, Australia.; Prince Charles Hospital Northside Clinical Unit, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.
Jazyk: angličtina
Zdroj: European journal of clinical investigation [Eur J Clin Invest] 2024 Oct; Vol. 54 (10), pp. e14259. Date of Electronic Publication: 2024 Jun 06.
DOI: 10.1111/eci.14259
Abstrakt: Background: The commonest echocardiographic measurement, left ventricular ejection fraction, can not necessarily predict mortality of recipients following heart transplantation potentially due to afterload dependency. Afterload-independent left ventricular stroke work index (LVSWI) is alternatively recommended by the current guideline; however, pulmonary artery catheters are rarely inserted in organ donors in most jurisdictions. We propose a novel non-invasive echocardiographic parameter, Pressure-Strain Product (PSP), as a potential surrogate of catheter-based LVSWI. This study aimed to investigate if PSP could correlate with catheter-based LVSWI in an ovine model of brain stem death (BSD) donors. The association between PSP and myocardial mitochondrial function in the post-transplant hearts was also evaluated.
Methods: Thirty-one female sheep (weight 47 ± 5 kg) were divided into two groups; BSD (n = 15), and sham neurologic injury (n = 16). Echocardiographic parameters including global circumferential strain (GCS) and global radial strain (GRS) and pulmonary artery catheter-based LVSWI were simultaneously measured at 8-timepoints during 24-h observation. PSP was calculated as a product of GCS or GRS, and mean arterial pressure for PSP circ or PSP rad , respectively. Myocardial mitochondrial function was evaluated following 6-h observation after heart transplantation.
Results: In BSD donor hearts, PSP circ (n = 96, rho = .547, p < .001) showed the best correlation with LVSWI among other echocardiographic parameters. PSP circ returned AUC of .825 to distinguish higher values of cardiomyocyte mitochondrial function (cut-off point; mean value of complex 1,2 O 2 Flux) in post-transplant hearts, which was greater than other echocardiographic parameters.
Conclusions: PSP circ could be used as a surrogate of catheter-based LVSWI reflecting mitochondrial function.
(© 2024 The Author(s). European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.)
Databáze: MEDLINE
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