The relationship between body composition and left ventricular performance in women with breast, lymphoma, or sarcoma cancer.

Autor: Mabudian L; Division of Cardiology, VCU Pauley Heart Center, Virginia Commonwealth University (VCU), PO Box 980335, Richmond, VA, USA., Reding K; University of Washington, Behavioral Nursing and Health Systems, Seattle, WA, USA., D'Agostino RB Jr; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Heiston EM; Division of Cardiology, VCU Pauley Heart Center, Virginia Commonwealth University (VCU), PO Box 980335, Richmond, VA, USA., Bellissimo MP; Division of Cardiology, VCU Pauley Heart Center, Virginia Commonwealth University (VCU), PO Box 980335, Richmond, VA, USA., Olson K; Division of Cardiology, VCU Pauley Heart Center, Virginia Commonwealth University (VCU), PO Box 980335, Richmond, VA, USA., Ntim WO; UNC School of Medicine, Novant Health Campus, Novant Health Heart & Vascular Institute, Charlotte, NC, USA., Klepin HD; Section On Hematology and Oncology, Department of Internal Medicine at Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Dressler EV; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Moore T; Section On Cardiovascular Medicine, Department of Internal Medicine at Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Jordan JH; Division of Cardiology, VCU Pauley Heart Center, Virginia Commonwealth University (VCU), PO Box 980335, Richmond, VA, USA.; Department of Biomedical Engineering, Virginia Commonwealth University (VCU), Richmond, VA, USA., O'Connell NS; Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA., Ladd A; Division of Cardiology, VCU Pauley Heart Center, Virginia Commonwealth University (VCU), PO Box 980335, Richmond, VA, USA., Weaver KE; Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Ky B; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Wagner LI; Department of Social Sciences and Health Policy, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.; Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA., Hackney MH; Department of Hematology, Oncology, and Palliative Care, Virginia Commonwealth University, Massey Cancer Center, Richmond, VA, USA., Lesser GJ; Section On Hematology and Oncology, Department of Internal Medicine at Wake Forest School of Medicine, Winston-Salem, North Carolina, USA., Hundley WG; Division of Cardiology, VCU Pauley Heart Center, Virginia Commonwealth University (VCU), PO Box 980335, Richmond, VA, USA. greg.hundley@vcuhealth.org.
Jazyk: angličtina
Zdroj: Cardio-oncology (London, England) [Cardiooncology] 2024 Jun 06; Vol. 10 (1), pp. 34. Date of Electronic Publication: 2024 Jun 06.
DOI: 10.1186/s40959-024-00233-1
Abstrakt: Background: To understand how body composition in those with elevated body mass index impacts left ventricular function decline during cancer treatment, we determined the association between baseline body mass index (BMI), intra-abdominal adipose tissue (IAT) and subcutaneous adipose tissue (SAT) with baseline to 3-month left ventricular ejection fraction (LVEF) change among women receiving potentially cardiotoxic chemotherapy for breast cancer, lymphoma, or sarcoma.
Methods: Women underwent potentially cardiotoxic chemotherapy, such as doxorubicin, cyclophosphamide, paclitaxel, and trastuzumab, for treatment of breast cancer, lymphoma, or sarcoma. We obtained magnetic resonance images (MRIs) of body composition and cardiac function prior to treatment, and then a repeat MRI for cardiac function assessment at three months into treatment. Analyses and assessment of abdominal adipose tissue volumes and LVEF outcomes were conducted by independent reviewers blinded to all patient identifiers. A general linear model was created to examine associations between adipose tissue depots, BMI, and 3-month LVEF change.
Results: Women (n = 210) aged 56 ± 11 years with breast cancer, lymphoma, and sarcoma were enrolled (n = 195, 14, 1 respectively). Baseline BMI, IAT, and SAT fat were independently associated with 3-month LVEF declines (p = 0.001 to 0.025 for all). After adjusting for baseline cardiovascular disease risk factors, BMI, IAT, and SAT, BMI remained the only variable associated with 3-month LVEF decline (p = 0.047).
Conclusions: These results suggest that factors other than abdominal adipose tissue or traditional cardiovascular risk factors may contribute to 3-month declines in LVEF among women with elevated BMI receiving potentially cardiotoxic chemotherapy. Further investigation should be conducted on psychosocial stress, physical activity, sleep, or diet.
Trial Registration: DETECTIV_NCT01719562, WF99112, & WF97415-NCT02791581.
(© 2024. The Author(s).)
Databáze: MEDLINE
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