Antimicrobial photodynamic therapy with methylene blue and its derivatives in animal studies: Systematic review.

Autor: Cardozo APM; Postgraduate Program in Biophotonics-Medicine Universidade Nove de Julho, Universidade Nove de Julho, São Paulo, Brazil., da Silva DFT; Postgraduate Program in Biophotonics-Medicine Universidade Nove de Julho, Universidade Nove de Julho, São Paulo, Brazil., Fernandes KPS; Postgraduate Program in Biophotonics-Medicine Universidade Nove de Julho, Universidade Nove de Julho, São Paulo, Brazil., Ferreira RC; Postgraduate Program in Biophotonics-Medicine Universidade Nove de Julho, Universidade Nove de Julho, São Paulo, Brazil., Lino-Dos-Santos-Franco A; Postgraduate Program in Biophotonics-Medicine Universidade Nove de Julho, Universidade Nove de Julho, São Paulo, Brazil., Rodrigues MFSD; Postgraduate Program in Biophotonics-Medicine Universidade Nove de Julho, Universidade Nove de Julho, São Paulo, Brazil., Motta LJ; Postgraduate Program in Biophotonics-Medicine Universidade Nove de Julho, Universidade Nove de Julho, São Paulo, Brazil., Cecatto RB; Postgraduate Program in Biophotonics-Medicine Universidade Nove de Julho, Universidade Nove de Julho, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Photodermatology, photoimmunology & photomedicine [Photodermatol Photoimmunol Photomed] 2024 Jul; Vol. 40 (4), pp. e12978.
DOI: 10.1111/phpp.12978
Abstrakt: Background: Infections are complications in the wound healing process, and their treatment can lead to antibiotic overuse and bacterial resistance. Antimicrobial photodynamic therapy (aPDT) is used to treat infectious diseases caused by fungi, viruses, or bacteria. Methylene blue (MB) and its derivatives are commonly used dyes in antimicrobial photodynamic therapy (aPDT-MB).
Methods: This study is a PRISMA systematic review of animal models used to discuss the usefulness and therapeutic parameters of aPDT-MB or its derivatives for treating infected skin wounds.
Results: After an extensive literature review, 13 controlled trials totaling 261 animals were selected to evaluate skin infection by leishmaniasis and cutaneous bacterial and fungal infections. All studies found results favoring the use of aPDT-MB. Great variability in parameters was found for radiant exposure from 12 to 360 J/cm 2 , MB diluted in saline solution or distilled water, irradiation time from 40 to 3600 s, irradiance most commonly at a maximum of 100 mW/cm 2 , and wavelength used mainly in the 630-670 nm range.
Conclusion: MB is a safe and promising agent used as a photosensitizer in aPDT for skin-infected lesions. There is great variability in the parameters found. Comparisons concerning concentration, irradiation time, and light intensity need to be performed.
(© 2024 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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