Determining the optimal daily gonadotropin dose to maximize the oocyte yield in elective egg freezing cycles.

Autor: Orvieto R; Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel. raoul.orvieto@sheba.health.gov.il.; Faculty of Medical and Health Science, Tel-Aviv University, Tel Aviv, Israel. raoul.orvieto@sheba.health.gov.il.; The Tarnesby-Tarnowski Chair for Family Planning and Fertility Regulation, Faculty of Medical and Health Science, Tel-Aviv University, Tel Aviv, Israel. raoul.orvieto@sheba.health.gov.il., Kadmon AS; Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel.; Arrow Program for Medical Education, Chaim Sheba Medical Center, Ramat Gan, Israel., Morag N; Faculty of Medical and Health Science, Tel-Aviv University, Tel Aviv, Israel., Segev-Zahav A; Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel., Nahum R; Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Ramat Gan, Israel.; Faculty of Medical and Health Science, Tel-Aviv University, Tel Aviv, Israel.
Jazyk: angličtina
Zdroj: Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2024 Jun 06; Vol. 22 (1), pp. 64. Date of Electronic Publication: 2024 Jun 06.
DOI: 10.1186/s12958-024-01236-4
Abstrakt: Objective: Ovarian stimulation (OS) with high daily gonadotropin doses are commonly offered to patients attempting social/elective egg freezing. However, the optimal daily gonadotropin dose that would allow a higher oocyte yield in the successive IVF cycle attempt was not settled and should be determined.
Patients and Methods: Data from all women admitted to our IVF unit for social/EEF, who underwent two consecutive IVF cycle attempts, with only those who used in the first attempt a starting daily gonadotropin dose of 300IU were analyzed. Patients characteristics and OS variables were used in an attempt to build a logistic model, helping in determining the daily gonadotropin dose that should be offered to patient during their second EEF attempt, aiming to further increase their oocyte yield.
Results: Three hundred and thirteen consecutive women undergoing two successive IVF cycle attempts were evaluated. Using logistic regression model, two equations were developed using individual patient-level data that determine the daily gonadotropin dose needed aiming to increase the oocyte yield in the successive cycle. (a): X=-0.514 + 2.87*A1 + 1.733*A2-0.194* (E2/1000) and (b): P = EXP(X) / [1 + EXP(X)].
Conclusions: Using the aforementioned equations succeeded in determining the daily gonadotropin dose that might result in increasing oocyte yield, with an AUC of 0.85. Any additional oocyte retrieved to these EEF patients might get them closer to fulfil their desire to parenthood.
(© 2024. The Author(s).)
Databáze: MEDLINE
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