Time-of-flight MRA of intracranial vessels at 7 T.

Autor: Cosottini M; Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy. mirco.cosottini@unipi.it.; Neuroradiology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy. mirco.cosottini@unipi.it., Calzoni T; Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy., Lazzarotti GA; Neuroradiology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy., Grigolini A; Neuroradiology Unit, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy., Bosco P; Laboratory of Medical Physics and Magnetic Resonance, IRCCS Stella Maris, Pisa, Italy., Cecchi P; Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.; Imago7 Research Foundation, Pisa, Italy., Tosetti M; Laboratory of Medical Physics and Magnetic Resonance, IRCCS Stella Maris, Pisa, Italy., Biagi L; Laboratory of Medical Physics and Magnetic Resonance, IRCCS Stella Maris, Pisa, Italy., Donatelli G; Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.; Imago7 Research Foundation, Pisa, Italy.
Jazyk: angličtina
Zdroj: European radiology experimental [Eur Radiol Exp] 2024 Jun 07; Vol. 8 (1), pp. 68. Date of Electronic Publication: 2024 Jun 07.
DOI: 10.1186/s41747-024-00463-z
Abstrakt: Background: Three-dimensional time-of-flight magnetic resonance angiography (TOF-MRA) is a largely adopted non-invasive technique for assessing cerebrovascular diseases. We aimed to optimize the 7-T TOF-MRA acquisition protocol, confirm that it outperforms conventional 3-T TOF-MRA, and compare 7-T TOF-MRA with digital subtraction angiography (DSA) in patients with different vascular pathologies.
Methods: Seven-tesla TOF-MRA sequences with different spatial resolutions acquired in four healthy subjects were compared with 3-T TOF-MRA for signal-to-noise and contrast-to-noise ratios as well as using a qualitative scale for vessel visibility and the quantitative Canny algorithm. Four patients with cerebrovascular disease (primary arteritis of the central nervous system, saccular aneurism, arteriovenous malformation, and dural arteriovenous fistula) underwent optimized 7-T TOF-MRA and DSA as reference. Images were compared visually and using the complex-wavelet structural similarity index.
Results: Contrast-to-noise ratio was higher at 7 T (4.5 ± 0.8 (mean ± standard deviation)) than at 3 T (2.7 ± 0.9). The mean quality score for all intracranial vessels was higher at 7 T (2.89) than at 3 T (2.28). Angiogram quality demonstrated a better vessel border detection at 7 T than at 3 T (44,166 versus 28,720 pixels). Of 32 parameters used for diagnosing cerebrovascular diseases on DSA, 27 (84%) were detected on 7-T TOF-MRA; the similarity index ranged from 0.52 (dural arteriovenous fistula) to 0.90 (saccular aneurysm).
Conclusions: Seven-tesla TOF-MRA outperformed conventional 3-T TOF-MRA in evaluating intracranial vessels and exhibited an excellent image quality when compared to DSA. Seven-tesla TOF-MRA might improve the non-invasive diagnostic approach to several cerebrovascular diseases.
Relevance Statement: An optimized TOF-MRA sequence at 7 T outperforms 3-T TOF-MRA, opening perspectives to its clinical use for noninvasive diagnosis of paradigmatic pathologies of intracranial vessels.
Key Points: • An optimized 7-T TOF-MRA protocol was selected for comparison with clinical 3-T TOF-MRA for assessing intracranial vessels. • Seven-tesla TOF-MRA outperformed 3-T TOF-MRA in both quantitative and qualitative evaluation. • Seven-tesla TOF-MRA is comparable to DSA for the diagnosis and characterization of intracranial vascular pathologies.
(© 2024. The Author(s).)
Databáze: MEDLINE
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